Accrual of functional redundancy along the lifespan and its effects on cognition.
Accrual of functional redundancy along the lifespan and its effects on cognition.
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DOI：
10.1016/j.neuroimage.2021.117737
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发表时间：
2021-04-01
期刊：
影响因子：
5.7
通讯作者：
Dayan E
中科院分区：
文献类型：
--
作者：
Sadiq MU;Langella S;Giovanello KS;Mucha PJ;Dayan E
尽管有必要了解大脑如何忍受与年龄相关的认知衰退的初始阶段，但迄今为止还没有定量的大脑机制。大脑可以通过冗余来承受认知老化的影响，冗余是工程和生物系统的一个设计特征，它需要替代元素的存在来保护它免受失败。在这里，我们研究了功能网络冗余和年龄之间的关系，在人类的寿命和他们的相互作用与认知，分析静息状态功能磁共振成像图像和认知措施，从579名受试者。网络范围内的冗余与年龄显着相关，表现出更强的联系与年龄比其他主要的拓扑措施，提出了一种模式的积累，然后老年下降。关键的是，冗余显着介导的年龄和执行功能之间的关联，与年龄和认知之间的反相关性较低的高冗余的主题。结果表明，功能冗余在整个生命周期中不断积累，减轻了年龄对认知的影响。
Despite the necessity to understand how the brain endures the initial stages of age-associated cognitive decline, no brain mechanism has been quantitatively specified to date. The brain may withstand the effects of cognitive aging through redundancy, a design feature in engineered and biological systems, which entails the presence of substitute elements to protect it against failure. Here, we investigated the relationship between functional network redundancy and age over the human lifespan and their interaction with cognition, analyzing resting-state functional MRI images and cognitive measures from 579 subjects. Network-wide redundancy was significantly associated with age, showing a stronger link with age than other major topological measures, presenting a pattern of accumulation followed by old-age decline. Critically, redundancy significantly mediated the association between age and executive function, with lower anti-correlation between age and cognition in subjects with high redundancy. The results suggest that functional redundancy accrues throughout the lifespan, mitigating the effects of age on cognition.
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影响因子：
4.3
作者：
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Bullmore E
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