Recent progress in ferroptosis: inducers and inhibitors.
Recent progress in ferroptosis: inducers and inhibitors.
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DOI：
10.1038/s41420-022-01297-7
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发表时间：
2022-12-29
影响因子：
7
通讯作者：
Guo, Zhong
中科院分区：
文献类型：
--
作者：
Du, Yunxi;Guo, Zhong
铁凋亡是一种新的铁依赖性细胞程序性死亡，其特征是铁积累和脂质过氧化。近年来，由于铁细胞凋亡与许多疾病的病理生理过程密切相关，因此引起了疾病治疗研究界的极大兴趣，以寻求揭示铁细胞凋亡的机制和关键靶点。最近的研究显示了一些关键靶点，如谷胱甘肽过氧化物酶4（GPX4）和系统Xc−，并且已经开发了几种诱导剂和抑制剂来调节这些关键靶点。随着新靶点的出现，铁凋亡诱导剂和抑制剂的研究也有了新的进展。诱导剂和抑制剂的选择和使用对相关工作至关重要。本文简要介绍了铁凋亡代谢途径中的重要调控靶点，列举和分类了常用的和新近开发的诱导剂和抑制剂，并讨论了它们的医学应用。文章最后对铁凋亡的未来研究方向进行了展望。
Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities in pursuit to reveal the mechanism and key targets of ferroptosis because ferroptosis is closely related to the pathophysiological processes of many diseases. Recent studies have shown some key targets, such as glutathione peroxidase 4 (GPX4) and System Xc−, and several inducers and inhibitors have been developed to regulate these key targets. With the emergence of new ferroptosis targets, studies on inducers and inhibitors have made new developments. The selection and use of inducers and inhibitors are very important for related work. This paper briefly introduces important regulatory targets in the ferroptosis metabolic pathway, lists and categorizes commonly used and recently developed inducers and inhibitors, and discusses their medical application. The paper ends of with potential future research direction for ferroptosis.
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ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
12.4
作者：
Balihodzic, Amar;Prinz, Felix;Dengler, Michael A.;Calin, George A.;Jost, Philipp J.;Pichler, Martin
通讯作者：
Pichler, Martin
影响因子：
5.8
作者：
Gao B;Wang L;Zhang N;Han M;Zhang Y;Liu H;Sun D;Xiao X;Liu Y
通讯作者：
Liu Y
影响因子：
10.8
作者：
Guan, Qingqing;Guo, Ruomi;Cao, Zhong
通讯作者：
Cao, Zhong