A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice.
A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice.
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DOI：
10.3390/md19090496
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发表时间：
2021-08-30
期刊：
影响因子：
5.4
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Huang X;Guan N;Li Q
在工程生物材料中重建细胞外基质（ECM）的典型类似物对于促进组织修复至关重要。在这里，我们报告了一种ECM模拟支架，通过增强血管形成和调节炎症，成功地加速伤口愈合。我们制备了一种含有褐藻多糖（BAP）和聚乙烯醇（PVA）的静电纺丝纤维。两种聚合物在体内应用PVA/BAP 2纤维时协同发挥功能;它开始减轻伤口部位的炎症并促进血管生成。我们的一系列体外和体内测试验证了PVA/BAP 2纤维的功效。特别是，PVA/BAP 2纤维加速了糖尿病小鼠全层皮肤伤口的修复，并诱导了最佳的新组织形成。总的来说，我们的研究结果表明，通过模拟ECM的功能，这种纤维作为一种工程生物材料可以有效地促进糖尿病伤口的愈合效率。我们的研究可能会启发开发新的，有效的，更安全的海洋来源的组织再生支架。
Reconstructing the typical analogue of extracellular matrix (ECM) in engineered biomaterials is essential for promoting tissue repair. Here, we report an ECM-mimetic scaffold that successfully accelerated wound healing through enhancing vascularization and regulating inflammation. We prepared an electrospun fiber comprising a brown alga-derived polysaccharide (BAP) and polyvinyl alcohol (PVA). The two polymers in concert exerted the function upon the application of PVA/BAP2 fiber in vivo; it started to reduce the inflammation and promote angiogenesis at the wound site. Our serial in vitro and in vivo tests validated the efficacy of PVA/BAP2 fiber. Particularly, PVA/BAP2 fiber accelerated the repair of a full-thickness skin wound in diabetic mice and induced optimal neo-tissue formation. Generally, our results suggest that, by mimicking the function of ECM, this fiber as an engineered biomaterial can effectively promote the healing efficiency of diabetic wounds. Our investigation may inspire the development of new, effective, and safer marine-derived scaffold for tissue regeneration.
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