Motor impulsivity in Parkinson disease: associations with COMT and DRD2 polymorphisms.
Motor impulsivity in Parkinson disease: associations with COMT and DRD2 polymorphisms.
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DOI：
10.1111/sjop.12113
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发表时间：
2014-06
影响因子：
2.1
通讯作者：
Corkin S
中科院分区：
文献类型：
--
作者：
Ziegler DA;Ashourian P;Wonderlick JS;Sarokhan AK;Prelec D;Scherzer CR;Corkin S
帕金森病（PD）是一种与年龄相关的脑退行性疾病，其特征在于运动、认知和精神症状。神经学家和神经科学家现在了解到，这种疾病的几种症状，包括幻觉和冲动控制行为，源于用于控制PD运动方面的多巴胺能药物。来自动物和人类的证据表明，影响多巴胺系统的基因的个体差异会影响PD患者对多巴胺能药物的反应。在这项研究中，我们测试了一个假设，即携带增加多巴胺信号的候选等位基因的多巴胺替代治疗患者表现出更大的运动冲动。我们研究了特发性PD患者的抑制能力（通过停止信号任务测量）与COMT Val 158 Met和DRD 2 C957 T多态性之间的关系。在停止信号任务上，COMT瓦尔/Met和Met/Met基因型携带者比瓦尔/瓦尔携带者更冲动，但我们没有发现DRD 2多态性与抑制能力之间的联系。这些结果支持了这一假设，即COMT的Met等位基因赋予PD患者行为冲动的风险增加，而DRD2多态性在确定PD患者是否表现出运动冲动形式的多巴胺过量方面似乎不太重要。
Parkinson disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, including hallucinations and impulse control behaviors, stem from the dopaminergic medications used to control the motor aspects of PD. Converging evidence from animals and humans suggests that individual differences in the genes that affect the dopamine system influence the response of PD patients to dopaminergic medication. In this study, we tested the hypothesis that patients taking dopamine replacement therapy who carry candidate alleles that increase dopamine signaling exhibit greater amounts of motor impulsivity. We examined the relation between inhibitory ability (measured by the Stop Signal Task) and polymorphisms of COMT Val158Met and DRD2 C957T in patients with idiopathic PD. On the Stop Signal Task, carriers of COMT Val/Met and Met/Met genotypes were more impulsive than Val/Val carriers, but we did not find a link between DRD2 polymorphisms and inhibitory ability. These results support the hypothesis that the Met allele of COMT confers an increased risk for behavioral impulsivity in PD patients, whereas DRD2 polymorphisms appear to be less important in determining whether PD patients exhibit a dopamine overdose in the form of motor impulsivity.
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