Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat.
Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat.
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DOI：
10.1016/j.neuroscience.2018.04.014
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发表时间：
2018-07-01
期刊：
影响因子：
3.3
通讯作者：
Peters CM
中科院分区：
文献类型：
--
作者：
Arora V;Martin TJ;Aschenbrenner CA;Hayashida K;Kim SA;Parker RA;Eisenach JC;Peters CM
社会心理因素，如焦虑、抑郁和灾难化，通常与慢性疼痛相关，也可能与术前存在的慢性术后疼痛（CPSP）风险增加相关。我们使用了重复社会失败（RSD）的范例，以诱导啮齿动物的心理社会应激前切口手术的爪子。混合效应生长曲线模型用于检查术后四周大鼠机械超敏反应的消退。手术后8天，进行免疫组织化学以检查脊髓中的胶质细胞活化以及诱发的神经元活化。在这里，我们记录了RSD导致手术前体重增加减少和抑郁症状增加。与非失败大鼠相比，暴露于RSD的大鼠在手术后在同侧爪中显示机械超敏反应延迟消退。先前暴露于RSD显著增加了同侧脊髓内的小胶质细胞活化和神经元敏化（pERK-IR）。总之，我们发现慢性社会压力改变了对手术损伤的神经生物学反应，导致恢复缓慢。此模型可能有助于未来的干预性研究，探讨抑郁症和CPSP风险之间的机制相互作用。
Psychosocial factors such as anxiety, depression and catastrophizing, commonly associated with established chronic pain, also may be associated with an increased risk of chronic postsurgical pain (CPSP) when present preoperatively. We used a repeat social defeat (RSD) paradigm to induce psychosocial stress in rodents prior to incisional surgery of the paw. Mixed effects growth curve models were utilized to examine resolution of mechanical hypersensitivity in rats for four weeks following surgery. Eight days following surgery, immunohistochemistry was conducted to examine glial activation as well as evoked neuronal activation in the spinal cord. Here we document that RSD resulted in reduced weight gain and increased depressive symptoms prior to surgery. Rats exposed to RSD displayed delayed resolution of mechanical hypersensitivity in the ipsilateral paw following surgery compared to non-defeated rats. Prior exposure to RSD significantly increased microglial activation and neuronal sensitization (pERK-IR) within the ipsilateral spinal cord. In conclusion, we found that chronic social stress alters the neurobiological response to surgical injury, resulting in slowed recovery. This model maybe useful for future interventional studies examining the mechanistic interactions between depression and risk of CPSP.
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