IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis.
IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis.
复制标题
波兰风湿关节炎患者的IL-17A，IL-17F和IL-23R基因多态性。
DOI：
10.1007/s00005-014-0319-5
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发表时间：
2015-06
影响因子：
3.2
通讯作者：
Wiland, Piotr
中科院分区：
文献类型：
--
作者：
Bogunia-Kubik, Katarzyna;Swierkot, Jerzy;Malak, Anna;Wysoczanska, Barbara;Nowak, Beata;Bialowas, Katarzyna;Gebura, Katarzyna;Korman, Lucyna;Wiland, Piotr
关键词：
在参与类风湿性关节炎（RA）发病机制的炎性细胞的复杂网络中，Th 17细胞最近被鉴定为促进自身免疫过程和关节破坏的关键细胞。IL-23/Th 17信号通路由IL-23/IL-23 R、IL-17 A和IL-17 F编码基因组成，代表了RA发展的候选途径，可能参与疾病易感性和对疾病进展的影响。本研究旨在确定IL-17 A（rs 2275913）、IL-17 F（rs763780）和IL-23 R（rs 11209026）基因多态性变体与RA易感性、进展和对TNF-α抑制剂治疗反应之间的相关性。89例患者和125名健康人进行了调查。发现IL-17 A多态性影响RA进展和对抗TNF治疗的反应。携带IL-17 A野生型基因型的女性患者更常出现4期（8/24 vs. 6/47; p = 0.058），并且在用TNF抑制剂治疗3个月后以更活跃的疾病（最高DAS 28评分>5.1）为特征（12/23 vs. 15/45; p = 0.040）。IL-17 F多态性似乎与疾病的易感性相关。IL-17 F微小变异（OR 3.97; p < 0.001）及其纯合性（OR 29.62; p < 0.001）在患者中比健康个体更常见。提示IL-17 A和IL-17 F基因多态性在RA发病中起重要作用。
Among the complex network of inflammatory cells involved in the pathogenesis of rheumatoid arthritis (RA), Th17 cells have recently been identified as key cells in the promotion of autoimmune processes, and joint destruction. The IL-23/Th17 signalling pathway, consisting of IL-23/IL-23R, IL-17A and IL-17F encoding genes, represents a candidate way for RA development with possible involvement in disease susceptibility and effect on disease progression. The present study aimed to determine the association between the polymorphic variants of the IL-17A (rs2275913), IL-17F (rs763780) and IL-23R (rs11209026) genes and RA susceptibility, progression and response to therapy with TNF-α inhibitors. Eighty-nine patients and 125 healthy individuals were investigated. The IL-17A polymorphism was found to affect RA progression and response to anti-TNF treatment. Female patients carrying the IL-17A wild-type genotype more frequently presented with stage 4 (8/24 vs. 6/47; p = 0.058) and were characterized by more active disease (the highest DAS28 score >5.1) after 3 months of therapy with the TNF inhibitors (12/23 vs. 15/45; p = 0.040). The IL-17F polymorphism appeared to be associated with susceptibility to the disease. The presence of the IL-17F minor variant (OR 3.97; p < 0.001) and its homozygosity (OR 29.62; p < 0.001) was more frequent among patients than healthy individuals. These results suggest that the polymorphisms within the IL-17A and IL-17F genes play a significant role in RA.
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影响因子：
5
作者：
Hazlett, J.;Stamp, L. K.;Hessian, P. A.
通讯作者：
Hessian, P. A.
影响因子：
2.8
作者：
Song, Gwan Gyu;Bae, Sang-Cheol;Lee, Young Ho
通讯作者：
Lee, Young Ho
影响因子：
2.7
作者：
Shibata, Tomoyuki;Tahara, Tomomitsu;Arisawa, Tomiyasu
通讯作者：
Arisawa, Tomiyasu
影响因子：
9.1
作者：
Arisawa, Tomiyasu;Tahara, Tomomitsu;Nakano, Hiroshi
通讯作者：
Nakano, Hiroshi
影响因子：
4.8
作者：
Aggarwal, S;Ghilardi, N;Gurney, AL
通讯作者：
Gurney, AL