Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses.
Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses.
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DOI：
10.1371/journal.pone.0088083
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Witte W
中科院分区：
文献类型：
--
作者：
Abdelbary MM;Wittenberg A;Cuny C;Layer F;Kurt K;Wieler LH;Walther B;Skov R;Larsen J;Hasman H;Fitzgerald JR;Smith TC;Wagenaar JA;Pantosti A;Hallin M;Struelens MJ;Edwards G;Böse R;Nübel U;Witte W
在21世纪初，一种特殊的MRSA克隆复合物（CC398）主要在欧洲的猪和养猪户中发现。从那时起，CC398已在世界范围内的各种动物物种中被检测到。我们通过在97个遗传管家基因座上的突变发现来研究CC398的群体结构，这些基因座分布沿着195个CC398分离株中的CC398染色体上，这些分离株收集自不同的国家和宿主物种，包括人类。这些标本中的大多数分离株都是从合作的微生物学家那里获得的，他们已经保存了多年。我们发现了96个双等位基因多态性，系统发育分析显示，CC398内的一个流行性亚克隆（被称为“进化枝（C）”）在马医院内和马医院之间传播，在那里它导致马的医院感染并在人员中定植。而分支（C）与S.虽然在兽医机构中的马中发现了金黄色葡萄球菌（p = 2×10−7），但在S. 金黄色葡萄球菌从人类感染中分离出来。
In the early 2000s, a particular MRSA clonal complex (CC398) was found mainly in pigs and pig farmers in Europe. Since then, CC398 has been detected among a wide variety of animal species worldwide. We investigated the population structure of CC398 through mutation discovery at 97 genetic housekeeping loci, which are distributed along the CC398 chromosome within 195 CC398 isolates, collected from various countries and host species, including humans. Most of the isolates in this collection were received from collaborating microbiologists, who had preserved them over years. We discovered 96 bi-allelic polymorphisms, and phylogenetic analyses revealed that an epidemic sub-clone within CC398 (dubbed ‘clade (C)’) has spread within and between equine hospitals, where it causes nosocomial infections in horses and colonises the personnel. While clade (C) was strongly associated with S. aureus from horses in veterinary-care settings (p = 2×10−7), it remained extremely rare among S. aureus isolates from human infections.
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影响因子：
5.2
作者：
Fessler, Andrea;Scott, Carly;Schwarz, Stefan
通讯作者：
Schwarz, Stefan
影响因子：
3.3
作者：
Anderson, Maureen E. C.;Lefebvre, Sandra L.;Weese, J. Scott
通讯作者：
Weese, J. Scott
影响因子：
3.3
作者：
Khanna, T.;Friendship, R.;Weese, J. S.
通讯作者：
Weese, J. S.
DOI：
10.1126/science.1182395
发表时间：
2010-01-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Harris SR;Feil EJ;Holden MT;Quail MA;Nickerson EK;Chantratita N;Gardete S;Tavares A;Day N;Lindsay JA;Edgeworth JD;de Lencastre H;Parkhill J;Peacock SJ;Bentley SD
通讯作者：
Bentley SD
影响因子：
7
作者：
Holden MT;Hsu LY;Kurt K;Weinert LA;Mather AE;Harris SR;Strommenger B;Layer F;Witte W;de Lencastre H;Skov R;Westh H;Zemlicková H;Coombs G;Kearns AM;Hill RL;Edgeworth J;Gould I;Gant V;Cooke J;Edwards GF;McAdam PR;Templeton KE;McCann A;Zhou Z;Castillo-Ramírez S;Feil EJ;Hudson LO;Enright MC;Balloux F;Aanensen DM;Spratt BG;Fitzgerald JR;Parkhill J;Achtman M;Bentley SD;Nübel U
通讯作者：
Nübel U