Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence
Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence
复制标题
戒除 28 天后依赖大麻使用者情绪处理过程中眶额活动和背侧纹状体连接的改变
DOI：
10.1007/s00213-017-4803-6
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发表时间：
2017-12
影响因子：
3.4
通讯作者：
Becker Benjamin
中科院分区：
文献类型：
--
作者：
Zimmermann Kaeli;Yao Shuxia;Heinz Marcel;Zhou Feng;Dau Wolfgang;Banger Markus;Weber Bernd;Hurlemann Ren;Becker Benjamin
完整的认知和情感功能对于成瘾治疗策略的长期成功至关重要。越来越多的证据表明，长期使用大麻与认知脑功能的持久改变之间存在关联。尽管最初的证据表明，依赖大麻的使用者在短期禁欲后情绪处理发生了变化，但在长期禁欲后情绪处理领域的适应仍有待确定。本研究调查了19名依赖大麻的使用者和18名匹配的非使用对照者在戒断期>结果相对于对照组，负性情绪刺激引起内侧眶额皮质（mOFC）活动增加，并且在依赖性大麻使用者中引起更强的mOFC-背侧纹状体和mOFC-杏仁核功能耦合（p< 0.022，FWE校正）。此外，大麻使用者在休息时mOFC-背侧纹状体功能连接增加（p< 0.03，FWE校正）。然而，积极的刺激和主观评级的效价和唤醒的处理在这两个groups.ConclusionsTogether，目前的研究结果提供了第一个证据，持久的情绪处理依赖大麻用户的改变。改变可能反映长期的神经适应作为慢性大麻使用或诱发大麻依赖性发展的危险因素的结果。
RationaleIntact cognitive and emotional functioning is vital for the long-term success of addiction treatment strategies. Accumulating evidence suggests an association between chronic marijuana use and lasting alterations in cognitive brain function. Despite initial evidence for altered emotion processing in dependent marijuana users after short abstinence periods, adaptations in the domain of emotion processing after longer abstinence remain to be determined.Objective and methodsUsing task-based and resting state fMRI, the present study investigated emotion processing in 19 dependent marijuana users and 18 matched non-using controls after an abstinence period of > 28 days.ResultsRelative to the control subjects, negative emotional stimuli elicited increased medial orbitofrontal cortex (mOFC) activity and stronger mOFC-dorsal striatal and mOFC-amygdala functional coupling in dependent marijuana users (p< 0.022, FWE-corrected). Furthermore, mOFC-dorsal striatal functional connectivity was increased at rest in marijuana users (p< 0.03, FWE-corrected). Yet, processing of positive stimuli and subjective ratings of valence and arousal were comparable in both groups.ConclusionsTogether, the present findings provide the first evidence for persisting emotion processing alterations in dependent marijuana users. Alterations might reflect long-term neural adaptations as a consequence of chronic marijuana use or predisposing risk factors for the development of marijuana dependence.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
2.9
作者：
K. Wolf;T. Raedler;K. Henke;F. Kiefer;R. Mass;M. Quante;K. Wiedemann
通讯作者：
K. Wolf;T. Raedler;K. Henke;F. Kiefer;R. Mass;M. Quante;K. Wiedemann
影响因子：
8.2
作者：
George, Olivier;Koob, George F.
通讯作者：
Koob, George F.
影响因子：
4.4
作者：
Simons, J;Correia, CJ;Carey, KB
通讯作者：
Carey, KB
影响因子：
3.3
作者：
Rabinak, Christine A.;Sripada, Chandra Sekhar;Angstadt, Mike;de Wit, Harriet;Phan, K. Luan
通讯作者：
Phan, K. Luan