Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations.
Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations.
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DOI：
10.1371/journal.pntd.0003115
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发表时间：
2014-09
影响因子：
3.8
通讯作者：
O'Neill SL
中科院分区：
文献类型：
--
作者：
Hoffmann AA;Iturbe-Ormaetxe I;Callahan AG;Phillips BL;Billington K;Axford JK;Montgomery B;Turley AP;O'Neill SL
黑腹果蝇的wMel感染被成功地转移到埃及伊蚊中，在那里它具有抑制登革热和其他虫媒病毒的潜力。2011年，该感染随后传播到昆士兰州凯恩斯附近的Yorkeys Knob和戈登韦尔的两个自然人群中。在这里，我们报告的稳定性的感染后，介绍和我们的特点的影响因素，在这两个人口的感染的持续动态。虽然沃尔巴克氏体感染始终保持高水平，并在这两个地点接近固定，但未感染蚊子的频率持续较低。这些未感染的蚊子在两个释放点表现出较弱的空间结构，虽然有一些聚集在戈登韦尔的两个地区。来自这两个地点的受感染雌性动物显示出与先前在实验室测试中建立的释放前模式一致的完美母体传播。在田间条件下>2年后，感染继续显示出跨多个生殖营养周期的完全细胞质不相容性，但持续的有害适合性效应，表明宿主效应随时间推移而稳定。这些结果表明，沃尔巴克氏体感染的稳定性及其对宿主的影响，当地入侵后，也强调了持续存在的未感染的个人在一个低频率最有可能是由于移民。wMel感染是引入埃及伊蚊蚊子种群的沃尔巴克氏体感染;如果感染在种群中持续存在，wMel可以提供对登革热的潜在抑制。我们发现，感染一直持续在一个高频率，因为它最初引入到两个自然人群在北昆士兰州，澳大利亚。这种通过雌性遗传的感染似乎可以完美地传播给田间的后代。当受感染的雄性与未受感染的雌性交配时，它继续产生高度的不相容性;这些雌性很可能以低频率作为移民进入种群。这些特征确保了感染在人群中保持高频率，但成本阻止了其快速传播。
The wMel infection of Drosophila melanogaster was successfully transferred into Aedes aegypti mosquitoes where it has the potential to suppress dengue and other arboviruses. The infection was subsequently spread into two natural populations at Yorkeys Knob and Gordonvale near Cairns, Queensland in 2011. Here we report on the stability of the infection following introduction and we characterize factors influencing the ongoing dynamics of the infection in these two populations. While the Wolbachia infection always remained high and near fixation in both locations, there was a persistent low frequency of uninfected mosquitoes. These uninfected mosquitoes showed weak spatial structure at both release sites although there was some clustering around two areas in Gordonvale. Infected females from both locations showed perfect maternal transmission consistent with patterns previously established pre-release in laboratory tests. After >2 years under field conditions, the infection continued to show complete cytoplasmic incompatibility across multiple gonotrophic cycles but persistent deleterious fitness effects, suggesting that host effects were stable over time. These results point to the stability of Wolbachia infections and their impact on hosts following local invasion, and also highlight the continued persistence of uninfected individuals at a low frequency most likely due to immigration. The wMel infection is a Wolbachia infection introduced into Aedes aegypti mosquito populations; wMel can provide potential suppression of dengue if the infection persists in populations. We show that the infection has persisted at a high frequency since its initial introduction into two natural populations in North Queensland, Australia. The infection, which is inherited through females, appears perfectly transmitted to offspring in the field. It has continued to produce a high level of incompatibility when infected males are mated with uninfected females; these females are likely to enter populations at a low frequency as migrants. These features ensure that the infection will stay at a high frequency in populations, but costs prevent its rapid spread.
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