Biomagnetic signatures of uncoupled gastric musculature.
Biomagnetic signatures of uncoupled gastric musculature.
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DOI：
10.1111/j.1365-2982.2009.01265.x
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发表时间：
2009-07
影响因子：
3.5
通讯作者：
Richards WO
中科院分区：
文献类型：
--
作者：
Bradshaw LA;Irimia A;Sims JA;Richards WO
胃慢波在健康胃的电合胞体中传播，在沿着胃窦大弯的起搏器区域以每分钟大约三次的速率产生，并向远端向幽门传播。已知疾病状态会改变正常的胃慢波。最近的研究表明使用生物磁技术来评估具有潜在诊断意义的胃慢波参数。我们提出了一项研究，其中当我们记录浆膜电位以及多通道生物磁信号和皮肤电位时，胃合胞体通过机械分裂而解耦。通过计算多通道生物磁记录的表面电流密度（SCD），我们能够量化胃慢波传播以及慢波的频率和幅度，并表明这些与浆膜电极的类似参数密切相关。我们发现主要的慢波频率是胃解偶联的不可靠指标，因为解偶联导致外部记录中出现不同频率的多个慢波源。分配在特定频率范围内的功率百分比表现出显着的划分后变化。在这项工作中，从 SCD 图确定的传播速度是解耦合的弱指标；我们认为，我们的 19 通道生物磁力计相对较低的空间分辨率混淆了慢波传播速度空间变化的表征。尽管如此，生物磁技术代表了一种准确测定胃慢波临床重要参数的非侵入性方法。
Gastric slow waves propagate in the electrical syncytium of the healthy stomach, being generated at a rate of approximately three times per minute in a pacemaker region along the greater curvature of the antrum and propagating distally towards the pylorus. Disease states are known to alter the normal gastric slow wave. Recent studies have suggested the use of biomagnetic techniques for assessing parameters of the gastric slow wave that have potential diagnostic significance. We present a study in which the gastric syncytium was uncoupled by mechanical division as we recorded serosal electric potentials along with multichannel biomagnetic signals and cutaneous potentials. By computing the surface current density (SCD) from multichannel biomagnetic recordings, we were able to quantify gastric slow wave propagation as well as the frequency and amplitude of the slow wave and to show that these correlate well with similar parameters from serosal electrodes. We found the dominant slow wave frequency to be an unreliable indicator of gastric uncoupling as uncoupling results in the appearance of multiple slow wave sources at various frequencies in external recordings. The percentage of power distributed in specific frequency ranges exhibited significant postdivision changes. Propagation velocity determined from SCD maps was a weak indicator of uncoupling in this work; we believe that the relatively low spatial resolution of our 19-channel biomagnetometer confounds the characterization of spatial variations in slow wave propagation velocities. Nonetheless, the biomagnetic technique represents a non-invasive method for accurate determination of clinically significant parameters of the gastric slow wave.
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影响因子：
--
作者：
BAUER, AJ;PUBLICOVER, NG;SANDERS, KM
通讯作者：
SANDERS, KM
影响因子：
4.6
作者：
Bradshaw, LA;Ladipo, JK;Richards, WO
通讯作者：
Richards, WO
影响因子：
3.5
作者：
Bradshaw, LA;Myers, AG;Richards, WO
通讯作者：
Richards, WO
影响因子：
3.5
作者：
Bradshaw, L. A.;Irimia, A.;Richards, W. O.
通讯作者：
Richards, W. O.
影响因子：
5.5
作者：
Hennig, GW;Hirst, GDS;Smith, TK
通讯作者：
Smith, TK