Diverse populations and enrollment in pediatric cancer clinical trials: Challenges and opportunities.
Diverse populations and enrollment in pediatric cancer clinical trials: Challenges and opportunities.
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DOI：
10.1002/pbc.28296
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发表时间：
2020-11
影响因子：
3.2
通讯作者：
Aristizabal P
中科院分区：
文献类型：
--
作者：
Aristizabal P
在过去的五十年里，儿童癌症的生存率显著提高，主要是由于临床试验（CT）的参与。2西班牙裔儿童白血病和淋巴瘤的发病率显著较高;然而，西班牙裔和非洲裔美国人的5年总生存率低于非西班牙裔白色（NHW）儿童。3-5较低的生存率至少部分归因于CT的入组率较低。1993年的《国立卫生研究院振兴法》规定将妇女和少数民族纳入CT。7然而，迄今为止，在大约10000个国家癌症研究所（NCI）CT中，只有2%有足够的少数民族参与者。8尽管NCI努力将少数民族纳入研究，但与NHWs相比，西班牙裔和非洲裔美国人的代表性严重不足（分别为1-7%和15%对67%）。8癌症CT的登记率甚至更低，西班牙裔为0.4-2.2%，非洲裔为5.4%，即使在NCI指定的癌症中心也是如此。8我们的工作表明，拉美裔在儿科癌症研究中的代表性不足。9因此，癌症结果数据主要基于来自NHWs的数据，提供的信息不足以充分评估少数群体的治疗效益。
Survival rates for pediatric cancer have improved significantly over the past five decades, 1 mainly due to clinical trial (CT) participation. 2 Hispanic children have a significantly higher incidence of leukemia and lymphoma; however, Hispanics and African Americans have poorer 5-year overall survival rates than their non-Hispanic White (NHW) counterparts. 3–5 Lower survival rates are at least partially attributable to lower enrollment in CTs. 6The National Institutes of Health Revitalization Act of 1993 mandated the inclusion of women and minorities in CTs. 7 However, to date, only 2% of approximately 10 000 National Cancer Institute (NCI) CTs have sufficient minority participants. 8 Despite the NCI’s efforts to include minorities in research, Hispanics and African Americans are severely underrepresented compared to NHWs (1–7% and 15% vs 67%, respectively). 8 Enrollment rates in cancer CTs are even lower at 0.4–2.2% for Hispanics and 5.4% for African Americans, even at NCI-designated cancer centers. 8 Our work demonstrated that Hispanics are underrepresented in pediatric cancer research. 9 Consequently, cancer outcomes data are primarily based on data from NHWs, providing inadequate information to adequately assess treatment benefits for minorities.
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影响因子：
3.2
作者：
Aristizabal, Paula;Singer, Jenelle;Martinez, Maria E.
通讯作者：
Martinez, Maria E.
影响因子：
6.2
作者：
Barrett, Nadine J.;Rodriguez, Elisa M.;Gage-Bouchard, Elizabeth A.
通讯作者：
Gage-Bouchard, Elizabeth A.
影响因子：
20.3
作者：
Bhatia, S;Sather, HN;Robison, LL
通讯作者：
Robison, LL
影响因子：
28.4
作者：
Loree, Jonathan M.;Anand, Seerat;Raghav, Kanwal
通讯作者：
Raghav, Kanwal
影响因子：
8.8
作者：
Strahlendorf, Caron;Pole, Jason D.;Sung, Lillian
通讯作者：
Sung, Lillian