Type 1 secretion system and effectors in Rickettsiales.
Type 1 secretion system and effectors in Rickettsiales.
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DOI：
10.3389/fcimb.2023.1175688
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
立克次体目中的专性细胞内细菌通过节肢动物媒介传播，并在人类和动物中引起危及生命的感染。虽然1型和4型分泌系统（T1SS和T4SS）已被确定在这一组，最广泛的研究立克次体T1SS和相关的效应已在埃里希体。这些研究揭示了T1SS效应子在病理生物学和免疫中的重要作用。为了逃避先天性免疫应答并促进细胞内存活，埃里希体和其他相关的专性病原体分泌多种T1SS效应物，其与与基本细胞过程相关的宿主靶标的多样化网络相互作用。T1SS效应子在感染期间具有多种功能活性，包括充当核调节蛋白和配体模拟物，其激活进化上保守的细胞信号传导途径。在埃里希体中，一系列新定义的主要免疫反应性蛋白已被确定为T1SS底物，并具有构象依赖性抗体表位。这些发现突出了T1SS效应蛋白在病理生物学和免疫学中未被充分认识和基本上未被表征的作用。本文综述了目前的知识，T1SS效应器在立克次氏体成员感染过程中的作用，并探讨了新发现的免疫反应蛋白作为潜在的T1SS底物和保护性宿主免疫反应的目标。
Obligate intracellular bacteria in the order Rickettsiales are transmitted by arthropod vectors and cause life-threatening infections in humans and animals. While both type 1 and type 4 secretion systems (T1SS and T4SS) have been identified in this group, the most extensive studies of Rickettsiales T1SS and associated effectors have been performed in Ehrlichia. These studies have uncovered important roles for the T1SS effectors in pathobiology and immunity. To evade innate immune responses and promote intracellular survival, Ehrlichia and other related obligate pathogens secrete multiple T1SS effectors which interact with a diverse network of host targets associated with essential cellular processes. T1SS effectors have multiple functional activities during infection including acting as nucleomodulins and ligand mimetics that activate evolutionarily conserved cellular signaling pathways. In Ehrlichia, an array of newly defined major immunoreactive proteins have been identified that are predicted as T1SS substrates and have conformation-dependent antibody epitopes. These findings highlight the underappreciated and largely uncharacterized roles of T1SS effector proteins in pathobiology and immunity. This review summarizes current knowledge regarding roles of T1SS effectors in Rickettsiales members during infection and explores newly identified immunoreactive proteins as potential T1SS substrates and targets of a protective host immune response.
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影响因子：
3.7
作者：
Green ER;Mecsas J
通讯作者：
Mecsas J
影响因子：
4.4
作者：
Lin M;Xiong Q;Chung M;Daugherty SC;Nagaraj S;Sengamalay N;Ott S;Godinez A;Tallon LJ;Sadzewicz L;Fraser C;Dunning Hotopp JC;Rikihisa Y
通讯作者：
Rikihisa Y
影响因子：
5.7
作者：
Farris TR;Zhu B;Wang JY;McBride JW
通讯作者：
McBride JW
影响因子：
16.6
作者：
通讯作者：
--
DOI：
10.1128/cdli.4.6.731-735.1997
发表时间：
1997-11-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Chen, SM;Cullman, LC;Walker, DH
通讯作者：
Walker, DH