Prospective memory in HIV-associated neurocognitive disorders (HAND): the neuropsychological dynamics of time monitoring.
Prospective memory in HIV-associated neurocognitive disorders (HAND): the neuropsychological dynamics of time monitoring.
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DOI：
10.1080/13803395.2013.776010
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发表时间：
2013
影响因子：
2.2
通讯作者：
Hiv Neurobehavioral Research Program Hnrp Group
中科院分区：
文献类型：
--
作者：
Doyle KL;Loft S;Morgan EE;Weber E;Cushman C;Johnston E;Grant I;Woods SP;Hiv Neurobehavioral Research Program Hnrp Group
在延迟间隔期间的策略监测被理论化为基于时间的前瞻性记忆（TB PM）的基本特征，其认知架构被认为在很大程度上依赖于额纹状体系统和执行功能。在55名HIV相关神经认知障碍（HAND）患者和108名血清阴性对照参与者中检查了这一假设，这些参与者接受了意图记忆筛选测试（MIST），在此期间测量了时间监测（时钟检查）行为。结果显示，HAND组和时钟检查频率之间存在显着的相互作用，其中HAND监测的个体在MIST的TB PM保留间隔中检查时钟的频率显着低于对照组。随后对HAND样本的分析显示，时钟检查的频率与整体TB表现呈正相关，也与回顾性记忆和语言流畅性的标准临床指标呈正相关。这些发现为越来越多的研究提供了支持，这些研究阐明了结核病PM对依赖于完整额纹状体系统的战略监测过程的依赖。艾滋病毒相关结核病战略时间监测缺陷可能表现为功能结局较差，包括药物不依从性和日常生活活动依赖性。未来的研究需要进一步阐明策略性时间监测的认知机制，以便为减少HAND相关的TB PM缺陷提供康复策略。
Strategic monitoring during a delay interval is theorized to be an essential feature of time-based prospective memory (TB PM), the cognitive architecture of which is thought to rely heavily on frontostriatal systems and executive functions. This hypothesis was examined in 55 individuals with HIV-associated neurocognitive disorders (HAND) and 108 seronegative comparison participants who were administered the Memory for Intentions Screening Test (MIST), during which time monitoring (clock checking) behavior was measured. Results revealed a significant interaction between HAND group and the frequency of clock checking, in which individuals with HAND monitored checked the clock significantly less often than the comparison group across the TB PM retention intervals of the MIST. Subsequent analyses in the HAND sample revealed that the frequency of clocking checking was positively related to overall TB performance, as well as to standard clinical measures of retrospective memory and verbal fluency. These findings add support to a growing body of research elucidating TB PM’s reliance on strategic monitoring processes dependent upon intact frontostriatal systems. HIV-associated TB strategic time monitoring deficits may manifest in poorer functioning outcomes, including medication non-adherence and dependence in activities of daily living. Future research is needed to further delineate the cognitive mechanisms underlying strategic time monitoring in order to advise rehabilitation strategies for reducing HAND related TB PM deficits.
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DOI：
10.1080/13803395.2011.651103
发表时间：
2012
影响因子：
2.2
作者：
Iudicello JE;Woods SP;Deutsch R;Grant I;HIV Neurobehavioral Research Program Hnrp Group
通讯作者：
HIV Neurobehavioral Research Program Hnrp Group
DOI：
10.1017/s1355617704102130
发表时间：
2004-05-01
影响因子：
2.6
作者：
Heaton, RK;Marcotte, TD;Grant, I
通讯作者：
Grant, I
影响因子：
3.2
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影响因子：
2.4
作者：
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通讯作者：
Carlesimo, Giovanni Augusto
影响因子：
17.7
作者：
Chang, L;Ernst, T;Grob, CS
通讯作者：
Grob, CS