Combined effects of aging and HIV infection on semantic verbal fluency: a view of the cortical hypothesis through the lens of clustering and switching.
Combined effects of aging and HIV infection on semantic verbal fluency: a view of the cortical hypothesis through the lens of clustering and switching.
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DOI：
10.1080/13803395.2011.651103
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发表时间：
2012
影响因子：
2.2
通讯作者：
HIV Neurobehavioral Research Program Hnrp Group
中科院分区：
文献类型：
--
作者：
Iudicello JE;Woods SP;Deutsch R;Grant I;HIV Neurobehavioral Research Program Hnrp Group
HIV相关的神经认知障碍（HAND）的特征通常被描述为“皮质下”，但在抗逆转录病毒治疗时代，随着HIV的衰老是否已经微妙地将HAND的表达转移到更“皮质”的障碍（例如，语义记忆存储的衰退）。我们通过检查语义流畅性及其组成过程（即，聚类和转换），在257个人在四个组分层的年龄（<40和≥ 50岁）和艾滋病毒血清状态。Jonckheere-Terpstra测试显示，HIV和衰老对整体语义（和字母）流畅性和切换的综合影响呈显著的单调趋势，但不包括聚类大小，在感染HIV的老年人中明显存在最大的缺陷。在老年艾滋病毒感染者队列中，较差的转换与自我报告的日常生活工具活动下降以及学习和执行功能缺陷有关，但与语义记忆无关。结果表明，HIV感染和衰老可能会对语义流畅性的执行成分产生不利的叠加效应（即，切换），而不是语义存储器存储的降级（即，簇大小），这是与这两种病症的组合额纹状体神经病理学负荷最一致的概况。
The profile of HIV-associated neurocognitive disorders (HAND) has classically been characterized as “subcortical”, but questions have arisen as to whether aging with HIV in the antiretroviral therapy era has subtlety shifted the expression of HAND into a more “cortical” disorder (e.g., decay of semantic memory stores). We evaluated this hypothesis by examining semantic fluency and its component processes (i.e., clustering and switching) in 257 individuals across four groups stratified by age (<40 and ≥ 50 years) and HIV serostatus. Jonckheere-Terpstra tests revealed significant monotonic trends for the combined effects of HIV and aging on overall semantic (and letter) fluency and switching, but not cluster size, with greatest deficits evident in the older adults with HIV infection. Within the older HIV-infected cohort, poorer switching was uniquely associated with self-reported declines in instrumental activities of daily living and deficits in learning and executive functions, but not semantic memory. Results suggest that HIV infection and aging may confer adverse additive effects on the executive components of semantic fluency (i.e., switching), rather than a degradation of semantic memory stores (i.e., cluster size), which is a profile that is most consistent with combined frontostriatal neuropathological burden of these two conditions.
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