Depression, anxiety, and prevalent diabetes in the Chinese population: findings from the China Kadoorie Biobank of 0.5 million people.
Depression, anxiety, and prevalent diabetes in the Chinese population: findings from the China Kadoorie Biobank of 0.5 million people.
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DOI：
10.1016/j.jpsychores.2013.09.008
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发表时间：
2013-12
影响因子：
4.7
通讯作者：
Chen, Zhengming
中科院分区：
文献类型：
--
作者：
Mezuk, Briana;Chen, Yiping;Yu, Canqing;Guo, Yu;Bian, Zheng;Collins, Rory;Chen, Junshi;Pang, Zengchang;Wang, Huijun;Peto, Richard;Que, Xiangsan;Zhang, Hui;Tan, Zhongwen;Kendler, Kenneth S.;Li, Liming;Chen, Zhengming
尽管之前进行了调查，但重度抑郁症 (MD) 与 2 型糖尿病 (T2DM) 之间的关联性质（特别是在中国成人中）以及广泛性焦虑症 (GAD) 与 T2DM 的相关性仍然存在不确定性。对来自中国嘉道理生物银行研究的横断面数据进行了分析，样本来自中国 10 个地理区域的约 500,000 名成年人。去年的 MD 和 GAD 是使用综合国际诊断清单进行评估的。 T2DM 的定义是，医生在 30 岁或以后自我报告诊断为糖尿病（“临床确诊”病例），或非空腹血糖≥11.1 mmol/L 或空腹血糖≥7.0 mmol/L，但之前没有糖尿病诊断（“筛查检测”病例）。 Logistic 回归用于评估 MD 和 GAD 与临床识别和筛查检测的 T2DM 之间的关系，并根据人口特征和健康行为进行调整。 T2DM 的患病率为 5.3%（临床确诊为 3.2%，筛查检测为 2.1%）。 MD 与临床诊断的 T2DM 显着相关（比值比 [OR]：1.75，95% 置信区间 (CI)：1.47 – 2.08），但与筛查检测的 T2DM 无关（OR：1.18，95% CI：0.92 – 1.51）。 GAD 与临床识别（OR：2.14，95% CI：1.60 – 2.88）和筛查检测（OR：1.44，95% CI：0.99 – 2.08）T2DM 相关。 MD、GAD 与 T2DM 之间的关系受到肥胖的调节。 MD 与临床确诊的 T2DM 相关，但与筛查检测的 T2DM 无关。 GAD 与临床识别和筛查检测的 T2DM 相关。 MD 和 T2DM 之间的关系在非肥胖人群中最为明显。
Despite previous investigation, uncertainty remains about the nature of the associations of major depression (MD) with type 2 diabetes mellitus (T2DM), particularly in adult Chinese, and the relevance of generalized anxiety disorder (GAD) for T2DM. Cross-sectional data from the China Kadoorie Biobank Study, a sample of approximately 500,000 adults from 10 geographically defined regions of China, were analyzed. Past year MD and GAD were assessed using the Composite International Diagnostic Inventory. T2DM was defined as either having self-reported physician diagnosis of diabetes at age 30 or later (“clinically-identified” cases) or having a non-fasting blood glucose ≥11.1 mmol/L or fasting blood glucose ≥7.0 mmol/L but no prior diagnosis of diabetes (“screen-detected” cases). Logistic regression was used to assess the relationship between MD and GAD with clinically-identified and screen-detected T2DM, adjusting for demographic characteristics and health behaviors. The prevalence of T2DM was 5.3% (3.2% clinically-identified and 2.1% screen-detected). MD was significantly associated with clinically-identified T2DM (Odds ratio [OR]: 1.75, 95% Confidence Interval (CI): 1.47 – 2.08), but not with screen-detected T2DM (OR: 1.18, 95% CI: 0.92 – 1.51). GAD was associated with both clinically-identified (OR: 2.14, 95% CI: 1.60 – 2.88) and screen-detected (OR: 1.44, 95% CI: 0.99 – 2.08) T2DM. The relationship between MD and GAD with T2DM was moderated by obesity. MD is associated with clinically-identified, but not screen-detected T2DM. GAD is associated with both clinically-identified and screen-detected T2DM. The relationship between MD and T2DM is strongest among those who are not obese.
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影响因子：
6.7
作者：
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通讯作者：
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Nouwen A;Nefs G;Caramlau I;Connock M;Winkley K;Lloyd CE;Peyrot M;Pouwer F;European Depression in Diabetes Research Consortium
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European Depression in Diabetes Research Consortium
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作者：
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Pouwer, F