Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans.
Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans.
复制标题
DOI：
10.1038/s41467-021-20939-5
复制
发表时间：
2021-01-28
影响因子：
16.6
通讯作者：
Chesler AT
中科院分区：
文献类型：
--
作者：
Case LK;Liljencrantz J;Madian N;Necaise A;Tubbs J;McCall M;Bradson ML;Szczot M;Pitcher MH;Ghitani N;Frangos E;Cole J;Bharucha-Goebel D;Saade D;Ogata T;Donkervoort S;Foley AR;Bönnemann CG;Olausson H;Bushnell MC;Chesler AT
压力感让我们感受到持续的压迫和身体的紧张。尽管近年来我们对皮肤触觉的了解有了显着增长，但如何检测深层组织感觉仍然不太清楚。在这里，我们对患有罕见感觉障碍的患者以及典型个体的神经阻滞进行定量感觉评估，以探讨检测无痛压力的神经和遗传机制。我们发现，当健康志愿者的有髓纤维功能被实验阻断时，感知无害压力的能力就会丧失，并且两名缺乏 Aβ 纤维的患者根本无法感受到无害压力。我们发现，7 名机械感受器 PIEZO2 基因有遗传性突变的个体，他们在触觉和本体感觉方面存在严重缺陷，但他们在感知压力方面几乎与健康对照受试者一样好。总之，这些数据支持 Aβ 传入神经在压力感觉中的作用，并表明存在一种未知的分子途径来检测它。深层压力传感的机制尚不完全清楚。在这里，作者证明，虽然两个缺乏 Aβ 纤维的个体表现出深部压力感应受损，但七个具有 PIEZO2 功能丧失突变的个体却表现出正常的深部压力反应。
The sensation of pressure allows us to feel sustained compression and body strain. While our understanding of cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations of patients with rare sensory disorders, as well as nerve blocks in typical individuals, to probe the neural and genetic mechanisms for detecting non-painful pressure. We show that the ability to perceive innocuous pressures is lost when myelinated fiber function is experimentally blocked in healthy volunteers and that two patients lacking Aβ fibers are strikingly unable to feel innocuous pressures at all. We find that seven individuals with inherited mutations in the mechanoreceptor PIEZO2 gene, who have major deficits in touch and proprioception, are nearly as good at sensing pressure as healthy control subjects. Together, these data support a role for Aβ afferents in pressure sensation and suggest the existence of an unknown molecular pathway for its detection. The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.
登录
查看更多内容
影响因子：
64.5
作者：
Li L;Rutlin M;Abraira VE;Cassidy C;Kus L;Gong S;Jankowski MP;Luo W;Heintz N;Koerber HR;Woodbury CJ;Ginty DD
通讯作者：
Ginty DD
影响因子：
5.5
作者：
MENSE, S;MEYER, H
通讯作者：
MEYER, H
影响因子：
3.3
作者：
Case LK;Liljencrantz J;McCall MV;Bradson M;Necaise A;Tubbs J;Olausson H;Wang B;Bushnell MC
通讯作者：
Bushnell MC
DOI：
10.1056/nejmoa1602812
发表时间：
2016-10-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Chesler AT;Szczot M;Bharucha-Goebel D;Čeko M;Donkervoort S;Laubacher C;Hayes LH;Alter K;Zampieri C;Stanley C;Innes AM;Mah JK;Grosmann CM;Bradley N;Nguyen D;Foley AR;Le Pichon CE;Bönnemann CG
通讯作者：
Bönnemann CG
影响因子：
1.8
作者：
Ludbrook, J;Dudley, H
通讯作者：
Dudley, H