Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?
Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?
复制标题
DOI：
10.1155/2018/9156478
复制
发表时间：
2018
影响因子：
--
通讯作者：
Li F
中科院分区：
文献类型：
--
作者：
Song C;Wang J;Kim B;Lu C;Zhang Z;Liu H;Kang H;Sun Y;Guan H;Fang Z;Li F
哺乳动物的许多生理过程，包括骨代谢，由昼夜节律钟系统调节，该昼夜节律钟系统由中央调节器、视交叉上核（SCN）和BMAL 1/CLOCK-PERs/BMAL 1系统的外周振荡器组成。各种骨转换标志物和骨代谢调节激素，如褪黑激素和甲状旁腺激素（PTH）显示昼夜节律性。根据先前的研究，由于轮班工作，睡眠限制或时钟基因敲除而导致的生物钟中断与骨质疏松症或其他骨代谢异常有关，显示了生物钟系统对维持骨代谢稳态的重要性。此外，骨质疏松症的常见原因，包括绝经后状态和衰老，与生物钟的变化有关。在我们之前的研究中，我们发现昼夜节律调节剂REV-ERBs的激动抑制破骨细胞分化并改善卵巢切除术诱导的小鼠骨丢失，这表明时钟基因可能是骨代谢异常的有希望的干预靶点。此外，在不同时间点的骨质疏松症干预措施可以提供不同程度的骨保护，这表明在骨质疏松症的临床治疗中考虑昼夜节律以获得最佳疗效的重要性。本文就生物节律与骨代谢的关系作一综述。
Numerous physiological processes of mammals, including bone metabolism, are regulated by the circadian clock system, which consists of a central regulator, the suprachiasmatic nucleus (SCN), and the peripheral oscillators of the BMAL1/CLOCK-PERs/CRYs system. Various bone turnover markers and bone metabolism-regulating hormones such as melatonin and parathyroid hormone (PTH) display diurnal rhythmicity. According to previous research, disruption of the circadian clock due to shift work, sleep restriction, or clock gene knockout is associated with osteoporosis or other abnormal bone metabolism, showing the importance of the circadian clock system for maintaining homeostasis of bone metabolism. Moreover, common causes of osteoporosis, including postmenopausal status and aging, are associated with changes in the circadian clock. In our previous research, we found that agonism of the circadian regulators REV-ERBs inhibits osteoclast differentiation and ameliorates ovariectomy-induced bone loss in mice, suggesting that clock genes may be promising intervention targets for abnormal bone metabolism. Moreover, osteoporosis interventions at different time points can provide varying degrees of bone protection, showing the importance of accounting for circadian rhythms for optimal curative effects in clinical treatment of osteoporosis. In this review, we summarize current knowledge about circadian rhythms and bone metabolism.
登录
查看更多内容
影响因子：
5.6
作者：
Chen L;Yang G
通讯作者：
Yang G
影响因子：
4.1
作者：
Gordon, Jonathan A. R.;Tye, Coralee E.;Goldberg, Harvey A.
通讯作者：
Goldberg, Harvey A.
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
Schibler, U
影响因子：
4
作者：
Blume, S. W.;Curtis, J. R.
通讯作者：
Curtis, J. R.
影响因子：
2.4
作者：
Al-Sobayil, F. A.
通讯作者：
Al-Sobayil, F. A.