A discrete fiber network finite element model of arterial elastin network considering inter-fiber crosslinking property and density.
A discrete fiber network finite element model of arterial elastin network considering inter-fiber crosslinking property and density.
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DOI：
10.1016/j.jmbbm.2022.105396
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发表时间：
2022-10
影响因子：
3.9
通讯作者：
Zhang, Yanhang
中科院分区：
文献类型：
--
作者：
Yu, Xunjie;Zhang, Yanhang
关键词：
细胞外基质(ECM)中的纤维间交联物在决定纤维网络的力学性能方面起着重要作用。离散纤维网络(DFN)模型已被用于研究纤维生物材料，但纤维间的交联物对ECM网络力学的贡献还不是很清楚。在这项研究中，根据测量的结构特征建立了动脉弹性蛋白网络的DFN模型，以研究纤维间的交联性和密度对网络的力学和纤维运动学的贡献。DFN是通过按照从多光子显微镜获得的纤维取向分布函数将线段随机放置到给定域中，直到达到期望的纤维面积分数来产生的。线段之间的交叉点被视为交叉链。然后将生成的DFN模型整合到ABAQUS有限元模型中，模拟等和非等双轴变形下的网络。光纤间交叉连接使用具有零(销钉连接)或无限(焊接连接)旋转刚度的连接器单元来建模。此外，系统地降低了纤维间的交联度，并研究了其对网络和纤维水平力学的影响。DFN模型对弹性蛋白网络的应力-应变行为具有良好的拟合和预测能力。虽然销钉和焊接接头似乎对网络的应力应变行为没有明显的影响，但交联性会影响局部纤维的力学和运动学。总体而言，我们的研究表明，纤维间的交联性对于ECM网络的多尺度力学和纤维运动学是重要的。
Inter-fiber crosslinks within the extracellular matrix (ECM) play important roles in determining the mechanical properties of the fibrous network. Discrete fiber network (DFN) models have been used to study fibrous biological material, however the contribution of inter-fiber crosslinks to the mechanics of the ECM network is not well understood. In this study, a DFN model of arterial elastin network was developed based on measured structural features to study the contribution of inter-fiber crosslinking properties and density to the mechanics and fiber kinematics of the network. The DFN was generated by randomly placing line segments into a given domain following a fiber orientation distribution function obtained from multiphoton microscopy until a desired fiber areal fraction was reached. Intersections between the line segments were treated as crosslinks. The generated DFN model was then incorporated into an ABAQUS finite element model to simulate the network under equi- and nonequi-biaxial deformation. The inter-fiber crosslinks were modeled using connector elements with either zero (pin joint) or infinite (weld joint) rotational stiffness. Furthermore, inter-fiber crosslinking density was systematically reduced and its effect on both network- and fiber-level mechanics was studied. The DFN model showed good fitting and predicting capabilities of the stress-strain behavior of the elastin network. While the pin and weld joints do not seem to have noticeable effect on the network stress-strain behavior, the crosslinking properties can affect the local fiber mechanics and kinematics. Overall, our study suggests that inter-fiber crosslinking properties are important to the multiscale mechanics and fiber kinematics of the ECM network.
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影响因子：
14
作者：
D'Amore A;Stella JA;Wagner WR;Sacks MS
通讯作者：
Sacks MS
影响因子：
3.5
作者：
Nerurkar, Nandan L.;Mauck, Robert L.;Elliott, Dawn M.
通讯作者：
Elliott, Dawn M.
影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
DOI：
10.1115/1.2354200
发表时间：
2006-12-01
影响因子：
1.7
作者：
Gilbert, Thomas W.;Sacks, Michael S.;Chancellor, Michael B.
通讯作者：
Chancellor, Michael B.
DOI：
10.1016/j.jmbbm.2014.07.016
发表时间：
2014-11
影响因子：
3.9
作者：
D'Amore, Antonio;Amoroso, Nicholas;Gottardi, Riccardo;Hobson, Christopher;Carruthers, Christopher;Watkins, Simon;Wagner, William R.;Sacks, Michael S.
通讯作者：
Sacks, Michael S.