From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterials.
From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterials.
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DOI：
10.1016/j.jmbbm.2014.07.016
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发表时间：
2014-11
影响因子：
3.9
通讯作者：
Sacks, Michael S.
中科院分区：
文献类型：
--
作者：
D'Amore, Antonio;Amoroso, Nicholas;Gottardi, Riccardo;Hobson, Christopher;Carruthers, Christopher;Watkins, Simon;Wagner, William R.;Sacks, Michael S.
在目前的工作中，我们证明了膜弹性体支架的介观平面内力学行为可以通过复制实际量化的纤维几何形状来模拟。弹性静电纺丝聚氨酯（ES-PEUU）支架，有和没有微粒夹杂物，被利用。模拟是从实验衍生的纤维网络几何形状，基于一系列的支架各向同性和各向异性的行为。根据可测量的几何参数（如纤维交叉点、连接性、方向和直径），选择这些参数以评价对宏观力学的影响。进行模拟，仅调整纤维材料模型参数以匹配宏观水平的机械测试数据。通过使用AFM的单个纤维机械测试在微观水平上进行纤维模型验证。结果表明，非常好的协议的实验数据，并揭示了形成扩展的优先纤维取向跨越整个模型空间。我们推测，这些新兴的结构可能是负责在静电纺丝支架中观察到的组织样宏观尺度行为。总之，建模方法对以下方面具有影响：（1）深入了解制造变量、结构和力学之间的复杂关系，以制造更多功能性器械/材料，（2）阐明细胞或颗粒夹杂物对整体结构力学的影响，以及（3）制造性能更好的组织替代物，可以概括天然组织力学。
In the present work, we demonstrate that the mesoscopic in-plane mechanical behavior of membrane elastomeric scaffolds can be simulated by replication of actual quantified fibrous geometries. Elastomeric electrospun polyurethane (ES-PEUU) scaffolds, with and without particulate inclusions, were utilized. Simulations were developed from experimentally-derived fiber network geometries, based on a range of scaffold isotropic and anisotropic behaviors. These were chosen to evaluate the effects on macro-mechanics based on measurable geometric parameters such as fiber intersections, connectivity, orientation, and diameter. Simulations were conducted with only the fiber material model parameters adjusted to match the macro-level mechanical test data. Fiber model validation was performed at the microscopic level by individual fiber mechanical tests using AFM. Results demonstrated very good agreement to the experimental data, and revealed the formation of extended preferential fiber orientations spanning the entire model space. We speculate that these emergent structures may be responsible for the tissue-like macroscale behaviors observed in electrospun scaffolds. To conclude, the modeling approach has implications for (1) gaining insight on the intricate relationship between fabrication variables, structure, and mechanics to manufacture more functional devices/materials, (2) elucidating the effects of cell or particulate inclusions on global construct mechanics, and (3) fabricating better performing tissue surrogates that could recapitulate native tissue mechanics.
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DOI：
10.1115/1.1318906
发表时间：
2000-12-01
影响因子：
1.7
作者：
Butler, DL;Goldstein, SA;Guilak, F
通讯作者：
Guilak, F
影响因子：
2.4
作者：
Jean, Aurelie;Engelmayr, George C., Jr.
通讯作者：
Engelmayr, George C., Jr.
影响因子：
14
作者：
D'Amore A;Stella JA;Wagner WR;Sacks MS
通讯作者：
Sacks MS
影响因子：
29.4
作者：
Amoroso, Nicholas J.;D'Amore, Antonio;Hong, Yi;Wagner, William R.;Sacks, Michael S.
通讯作者：
Sacks, Michael S.
影响因子：
14
作者：
Bashur, Chris A.;Dahlgren, Linda A.;Goldstein, Aaron S.
通讯作者：
Goldstein, Aaron S.