Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03.
Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03.
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DOI：
10.1371/journal.pone.0087792
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Tohma S
中科院分区：
文献类型：
--
作者：
Furukawa H;Kawasaki A;Oka S;Ito I;Shimada K;Sugii S;Hashimoto A;Komiya A;Fukui N;Kondo Y;Ito S;Hayashi T;Matsumoto I;Kusaoi M;Amano H;Nagai T;Hirohata S;Setoguchi K;Kono H;Okamoto A;Chiba N;Suematsu E;Katayama M;Migita K;Suda A;Ohno S;Hashimoto H;Takasaki Y;Sumida T;Nagaoka S;Tsuchiya N;Tohma S
已经进行了许多关于人类白细胞抗原（HLA）等位基因频率与系统性红斑狼疮（SLE）易感性之间关系的研究。然而，与 HLA-DRB1 等位基因的保护性关联的报道很少。在这里，我们寻找日本 SLE 患者中 HLA-DRB1 的保护性和易感性等位基因。在日本 SLE 患者中进行了 HLA-DRB1 关联研究。通过连续消除具有最强关联的每个等位基因的携带者来分析相对倾向效应。我们还探讨了 DRB1 等位基因与 SLE 表型的关联，包括自身抗体的存在和临床表现。某些 DRB1 等位基因的显着不同的载体频率被发现与 SLE 相关，如下：DRB1*15:01 增加（P = 5.48×10−10，校正 P (Pc) = 1.59×10−8，比值比 [OR] 2.17，95% 置信区间 [CI] 1.69–2.79），降低DRB1*13:02 (P = 7.17×10−5, Pc = 0.0020，OR 0.46，95% CI 0.34–0.63）并降低 DRB1*14:03（P = 0.0010，Pc = 0.0272，OR 0.34，95% CI 0.18–0.63）。此外，“*15:01/*13:02 或 *14:03”基因型往往与 SLE 呈负相关（P = 0.4209，OR 0.66），尽管当与 *13:02 或 *14:03 以外的等位基因一起存在时，与 *15:01 存在显着的正相关。 （P = 1.79×10−11，OR 2.39，95% CI 1.84–3.10）。 *13:02和*14:03的这种保护作用也在具有不同临床表型的SLE患者中得到证实。据我们所知，这是日本人群中 HLA-DRB1*13:02 和 *14:03 的携带频率与 SLE 之间存在保护性关联的第一份报告。
Many studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic lupus erythematosus (SLE) have been performed. However, few protective associations with HLA-DRB1 alleles have been reported. Here, we sought protective, as well as predispositional, alleles of HLA-DRB1 in Japanese SLE patients. An association study was conducted for HLA-DRB1 in Japanese SLE patients. Relative predispositional effects were analyzed by sequential elimination of carriers of each allele with the strongest association. We also explored the association of DRB1 alleles with SLE phenotypes including the presence of autoantibody and clinical manifestations. Significantly different carrier frequencies of certain DRB1 alleles were found to be associated with SLE as follows: increased DRB1*15:01 (P = 5.48×10−10, corrected P (Pc) = 1.59×10−8, odds ratio [OR] 2.17, 95% confidence interval [CI] 1.69–2.79), decreased DRB1*13:02 (P = 7.17×10−5, Pc = 0.0020, OR 0.46, 95% CI 0.34–0.63) and decreased DRB1*14:03 (P = 0.0010, Pc = 0.0272, OR 0.34, 95% CI 0.18–0.63). Additionally, the “*15:01/*13:02 or *14:03” genotype tended to be negatively associated with SLE (P = 0.4209, OR 0.66), despite there being significant positive associations with *15:01 when present together with alleles other than *13:02 or *14:03 (P = 1.79×10−11, OR 2.39, 95% CI 1.84–3.10). This protective effect of *13:02 and *14:03 was also confirmed in SLE patients with different clinical phenotypes. To the best of our knowledge, this is the first report of a protective association between the carrier frequencies of HLA-DRB1*13:02 and *14:03 and SLE in the Japanese population.
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影响因子：
3.7
作者：
Furukawa H;Oka S;Shimada K;Sugii S;Ohashi J;Matsui T;Ikenaka T;Nakayama H;Hashimoto A;Takaoka H;Arinuma Y;Okazaki Y;Futami H;Komiya A;Fukui N;Nakamura T;Migita K;Suda A;Nagaoka S;Tsuchiya N;Tohma S
通讯作者：
Tohma S
影响因子：
11.2
作者：
Madeleine, Margaret M.;Johnson, Lisa G.;Galloway, Denise A.
通讯作者：
Galloway, Denise A.
影响因子：
--
作者：
BLACK, CM;WELSH, KI;BATCHELOR, JR
通讯作者：
BATCHELOR, JR
影响因子：
2.1
作者：
HASHIMOTO, H;NISHIMURA, Y;HIROSE, S
通讯作者：
HIROSE, S
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y