Genome-wide linkage and peak-wide association study of obesity-related quantitative traits in Caribbean Hispanics.
Genome-wide linkage and peak-wide association study of obesity-related quantitative traits in Caribbean Hispanics.
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DOI：
10.1007/s00439-010-0916-2
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发表时间：
2011-02
期刊：
影响因子：
5.3
通讯作者：
Sacco RL
中科院分区：
文献类型：
--
作者：
Dong C;Beecham A;Slifer S;Wang L;McClendon MS;Blanton SH;Rundek T;Sacco RL
虽然在美国，肥胖在西班牙裔人中比非西班牙裔白人更普遍，但对这一人群中相关性状的遗传病因知之甚少。为了确定影响非墨西哥裔西班牙裔肥胖的遗传位点，我们对来自100个加勒比海西班牙裔家庭的1，390名受试者进行了全基因组连锁扫描，这些受试者具有6个与肥胖相关的数量性状：体重指数（BMI），体重，腰围，腰臀比，腹部和平均三头肌皮褶厚度，调整了显著的人口统计学和生活方式因素。然后，我们进行了关联分析的连锁峰和FTO基因在一个独立的社区为基础的西班牙裔子队列（N = 652，64%的加勒比海西班牙裔）从北方曼哈顿研究。1 q43上的连锁证据最强，体重的多点LOD评分为2.45（p = 0.0004）。在1 q43（LOD = 2.03）、14 q32（LOD = 2.17）、16 p12（LOD = 2.27）和体重（LOD = 2.26）以及16 q23 -24（LOD = 2.32）上也发现了LOD > 2.0的暗示性连锁证据。在染色体1 q43和16 p12以及FTO基因上的连锁峰的1-LOD单位下区域的6，440个单核苷酸多态性（SNP）的关联分析中，我们发现两个SNP 1 q43上的一个SNP（rs6665519和rs669231）和一个FTO SNP（rs 12447427）与BMI或体重显著相关。我们的研究结果表明，除了FTO，多个遗传位点，特别是那些在1 q43区域，可能有助于在加勒比海西班牙裔肥胖相关的数量性状的变化。
Although obesity is more prevalent in Hispanics than non-Hispanic whites in the United States, little is known about the genetic etiology of the related traits in this population. To identify genetic loci influencing obesity in non-Mexican Hispanics, we performed a genome-wide linkage scan in 1,390 subjects from 100 Caribbean Hispanic families on six obesity-related quantitative traits: body mass index (BMI), body weight, waist circumference, waist-to-hip ratio, abdominal and average triceps skinfold thickness after adjusting for significant demographic and lifestyle factors. We then carried out an association analysis of the linkage peaks and the FTO gene in an independent community-based Hispanic subcohort (N = 652, 64% Caribbean Hispanics) from the Northern Manhattan Study. Evidence of linkage was strongest on 1q43 with multipoint LOD score of 2.45 (p = 0.0004) for body weight. Suggestive linkage evidence of LOD > 2.0 was also identified on 1q43 for BMI (LOD = 2.03), 14q32 for abdominal skinfold thickness (LOD = 2.17), 16p12 for BMI (LOD = 2.27) and weight (LOD = 2.26), and 16q23–24 for average triceps skinfold thickness (LOD = 2.32). In the association analysis of 6,440 single nucleotide polymorphisms (SNPs) under 1-LOD unit down regions of our linkage peaks on chromosome 1q43 and 16p12 as well as in the FTO gene, we found that two SNPs (rs6665519 and rs669231) on 1q43 and one FTO SNP (rs12447427) were significantly associated with BMI or body weight after adjustment for multiple testing. Our results suggest that in addition to FTO, multiple genetic loci, particularly those on 1q43 region, may contribute to the variations in obesity-related quantitative traits in Caribbean Hispanics.
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影响因子：
9.8
作者：
Arya, R;Duggirala, R;Stern, MP
通讯作者：
Stern, MP
影响因子：
9.8
作者：
Feitosa, MF;Borecki, IB;Province, MA
通讯作者：
Province, MA
影响因子：
4.9
作者：
Chen, W;Li, S;Berenson, GS
通讯作者：
Berenson, GS
影响因子：
2.9
作者：
Moslehi, R;Goldstein, AM;Bergen, AW
通讯作者：
Bergen, AW
影响因子：
2.1
作者：
Gao, Xiaoyi;Stamier, Joshua;Martin, Eden R.
通讯作者：
Martin, Eden R.