Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention.
Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention.
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DOI：
10.1002/oby.20777
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发表时间：
2014-07
期刊：
影响因子：
6.9
通讯作者：
Wing, Rena R.
中科院分区：
文献类型：
--
作者：
Unick, Jessica L.;Hogan, Patricia E.;Neiberg, Rebecca H.;Cheskin, Lawrence J.;Dutton, Gareth R.;Evans-Hudnall, Gina;Jeffery, Robert;Kitabchi, Abbas E.;Nelson, Julie A.;Pi-Sunyer, F. Xavier;West, Delia Smith;Wing, Rena R.
生活方式干预措施的减肥效果各不相同，但预测长期成功却很困难。我们研究了在治疗的前 2 个月内使用不同体重减轻阈值来预测 1 年结果的效用。参与者包括 2327 名患有 2 型糖尿病的成年人 (BMI:35.8±6.0)，随机接受 Look AHEAD 试验的强化生活方式干预 (ILI)。 ILI 包括每周一次的行为课程，旨在增加体力活动和减少热量摄入。计算1个月、2个月和1年的体重变化。与最初体重减轻 ≥2% 的参与者相比，在第 1 个月未能实现体重减轻 ≥2% 的参与者在第 1 年也未能实现体重减轻 ≥10% 的可能性高出 5.6 (95% CI:4.5,7.0) 倍。当在第 2 个月使用 3% 体重减轻阈值时，这些几率增加到 11.6 (95% CI:8.6,15.6)。在第 1 个月和第 2 个月分别未能达到 ≥2% 和 ≥3% 阈值的个体中，只有 15.2% 和 8.2% 在第 1 年继续实现 ≥10% 体重减轻。考虑到初始体重减轻和 1 年体重减轻之间的关联，治疗的前几个月可能会出现体重减轻的情况。是识别那些人的最佳时机 不成功并利用救援力量。
Weight losses in lifestyle interventions are variable, yet prediction of long-term success is difficult. We examined the utility of using various weight loss thresholds in the first 2 months of treatment for predicting 1-year outcomes. Participants included 2327 adults with type 2 diabetes (BMI:35.8±6.0) randomized to the intensive lifestyle intervention (ILI) of the Look AHEAD trial. ILI included weekly behavioral sessions designed to increase physical activity and reduce caloric intake. 1-month, 2-month, and 1-year weight changes were calculated. Participants failing to achieve a ≥2% weight loss at Month 1 were 5.6 (95% CI:4.5,7.0) times more likely to also not achieve a ≥10% weight loss at Year 1, compared to those losing ≥2% initially. These odds were increased to 11.6 (95% CI:8.6,15.6) when using a 3% weight loss threshold at Month 2. Only 15.2% and 8.2% of individuals failing to achieve the ≥2% and ≥3% thresholds at Months 1 and 2 respectively, go on to achieve a ≥10% weight loss at Year 1. Given the association between initial and 1-year weight loss, the first few months of treatment may be an opportune time to identify those who are unsuccessful and utilize rescue efforts.
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影响因子：
3.1
作者：
Carels, Robert A.;Wott, Carissa B.;Koball, Afton
通讯作者：
Koball, Afton
影响因子：
16.2
作者：
Wing RR;Lang W;Wadden TA;Safford M;Knowler WC;Bertoni AG;Hill JO;Brancati FL;Peters A;Wagenknecht L;Look AHEAD Research Group
通讯作者：
Look AHEAD Research Group
影响因子：
--
作者：
Jakicic, John M.;Marcus, Bess H.;Janney, Carol
通讯作者：
Janney, Carol
影响因子：
3.5
作者：
Elfhag, Kristina;Rossner, Stephan
通讯作者：
Rossner, Stephan
DOI：
10.1002/j.1550-8528.1995.tb00466.x
发表时间：
1995-09-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
BLACKBURN, G
通讯作者：
BLACKBURN, G