Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex.
Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex.
复制标题
克罗尼奇·西尼斯（Clonorchis sinensis）感染调节了关键的细胞因子，以影响受性别影响的基本免疫反应。
DOI：
10.1371/journal.pntd.0010726
复制
发表时间：
2022-09
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
蠕虫感染可以调节宿主的免疫反应，最终形成相关疾病的发病率和死亡率。我们研究了229名中国东南部华支睾吸虫感染者和60名非华支睾吸虫感染者血清中必需免疫反应的关键细胞因子。检测血清抗蠕虫特异性IgG和IgE。感染C.中华绒螯蟹的抗原特异性IgG和IgE水平显著高于其它两种动物，且与粪便中虫卵数呈正相关。然而，与感染水平相似的男性相比，在女性中观察到IgE抗体的增强较少。C.中华绒螯蟹感染后，血清中Th 1型细胞因子（IL-1β、IL-2、IL-12 p70、IFN-γ和TNF-α）、Th 2型细胞因子（IL-4）和Th 17型细胞因子（IL-17 A）均明显降低，且随感染强度的增加而降低。值得注意的是，这些表型在女性中比在男性中更显著。虽然C.尽管中华按蚊感染与肝胆疾病的发生有关，但抑制的细胞因子谱与肝胆疾病的发病率之间无显著相关性。我们的研究表明C.感染与人体免疫功能低下密切相关。性别差异影响华支睾吸虫病的免疫环境。这项研究提供了一个更好的理解蠕虫如何影响免疫反应，并导致长期的免疫交替在人类与C。中华感染华支睾吸虫，又名肝吸虫，生活于人体胆管系统，是东亚地区的地方病。慢性C.感染中华民国而不加以治疗，可导致严重的疾病，并使人容易患上胆管癌。蠕虫感染能够调节宿主的免疫应答，影响感染的转归，但C.目前尚不清楚是否有中华按蚊感染。在这项研究中，我们分析了来自中国华支睾吸虫病流行区个人的血清样本。我们找到了C。中华按蚊感染引起成虫抗原特异性IgG和IgE升高，但引起必需免疫应答的关键细胞因子水平降低。Th 1型细胞因子（IL-1β、IL-2、IL-12 p70、IFN-γ和TNF-α）、Th 2型细胞因子（IL-4）以及Th 17型细胞因子（IL-17 A）随着感染强度的增加而呈下降趋势。此外，女性表现出更显着的细胞因子的变化相比，男性具有相似的感染强度。研究表明，C.华支睾吸虫感染与人体免疫功能低下有关，免疫功能低下可能是华支睾吸虫病转归的重要因素。在华支睾吸虫病的预防和免疫调查中应考虑到性二态性。
Infection with helminths can modulate the host immune response, which ultimately shape morbidity and mortality of the associated diseases. We studied key cytokines for essential immune response in sera from 229 southeastern China individuals infected with Clonorchis sinensis and 60 individuals without C. sinensis infection, and measured serum specific IgG and IgE against worms in these people. Individuals infected with C. sinensis had significantly higher antigen-specific IgG and IgE levels, which were positively correlated with egg counts in feces. However, less enhancement of IgE antibody was observed in females when compared to males with similar infection levels. C. sinensis infection caused diminished Th1 cytokines (IL-1β, IL-2, IL-12p70, IFN-γ and TNF-α), Th2 cytokine (IL-4), as well as Th17 cytokine (IL-17A) in sera, which showed decreasing trend by infection intensity. Notably, these phenotypes were more significant in females than those in males. Although C. sinensis infection is associated with the development of hepatobiliary diseases, there was no significant correlation between the dampened cytokine profiles and the hepatobiliary morbidities. Our study indicates C. sinensis infection is strongly related to the immune suppression in human. Sex differences shape the immune milieus of clonorchiasis. This study provides a better understanding of how worms affect immune responses and cause a long-term immune alternation in humans with C. sinensis infection. Clonorchis sinensis, also known as the liver fluke, lives in human bile duct system and is endemic in East Asia. Chronic C. sinensis infection without treatment can result in serious illness and predispose the human to bile duct cancer. Helminth infection is able to modulate the host immune response and influence the outcome of infection, but the immune characteristics of C. sinensis infection is not yet known. In this study, we analyzed serum samples from individuals living in endemic areas with clonorchiasis in China. We found C. sinensis infection caused increased specific IgG and IgE to adult worm antigens, but diminished levels of key cytokines for essential immune response. Th1 cytokines (IL-1β, IL-2, IL-12p70, IFN-γ and TNF-α), Th2 cytokine (IL-4), as well as Th17 cytokine (IL-17A) showed decreasing trend by infection intensity. Moreover, females exhibited more significant cytokine variation compared to males with similar infection intensity. Our study indicates that C. sinensis infection is related to immune suppression in human, which might contribute to the outcome of clonorchiasis. The sexual dimorphism needs to be considered in the clonorchiasis prophylaxis and immune investigation.
登录
查看更多内容
影响因子：
3.9
作者：
Chang JI;Lee K;Kim D;Yang JI;Park JK;Choi K;Kang SH;Lee KH;Lee KT;Lee JK;Park SM;Park JK
通讯作者：
Park JK
影响因子：
5.7
作者：
Liu X;Wu M;Liu Y;Li J;Yang D;Jiang L
通讯作者：
Jiang L
影响因子：
16.8
作者：
Babu S;Nutman TB
通讯作者：
Nutman TB
DOI：
10.1016/j.bbrc.2013.10.042
发表时间：
2013-11-08
影响因子：
3.1
作者：
Aomatsu, Megumi;Kato, Takayuki;Kitagawa, Seiichi
通讯作者：
Kitagawa, Seiichi
影响因子：
2.7
作者：
Deng, Zhuo-Hui;Fang, Yue-Yi;Liu, Meng-Ran
通讯作者：
Liu, Meng-Ran