Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study.
Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study.
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DOI：
10.5009/gnl15323
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发表时间：
2016-09-15
期刊：
影响因子：
3.4
通讯作者：
Kim BS
中科院分区：
文献类型：
--
作者：
Song MJ;Park YS;Song HJ;Park SJ;Ahn JY;Choi KD;Lee GH;Jung HY;Yook JH;Kim BS
妊娠相关胃癌是一种罕见的疾病。本病例对照研究旨在探讨妊娠相关性胃癌的临床病理特征及影响预后的因素。确定了1991年至2012年期间因妊娠相关性胃癌而到我们的三级转诊医院就诊的所有连续患者。两个年龄，性别和阶段匹配的控制，为每个案件也确定了从记录。记录临床病理学、妇科学和肿瘤学结局。对雌激素受体、孕激素受体、表皮生长因子受体、人表皮生长因子受体和E-钙粘蛋白进行免疫组织化学染色。对成纤维细胞生长因子受体2进行荧光原位杂交。妊娠相关胃癌组和对照组的中位总生存率分别为7.0个月和15.0个月（p=0.189）。预后不良的因素包括晚期和肿瘤位于胃体或整个胃，而不是妊娠状态或E-钙粘蛋白的丢失。妊娠相关胃癌从诊断到治疗的时间较长（21天vs 7天，p=0.021）。两组在受体或E-钙粘蛋白的表达上没有差异。妊娠相关性胃癌预后差可能与肿瘤的分期和部位有关，而与妊娠本身无关。
Pregnancy-associated gastric cancer is a rare condition. This case-control study was performed to identify the clinicopathological features and prognostic factors of pregnancy-associated gastric cancer. All consecutive patients who presented to our tertiary referral hospital with pregnancy-associated gastric cancer from 1991 to 2012 were identified. Two age-, sex-, and stage-matched controls for each case were also identified from the records. Clinicopathological, gynecological, and oncological outcomes were recorded. Immunohistochemical staining was performed for estrogen receptor, progesterone receptor, epidermal growth factor receptor, human epidermal growth factor receptor, and E-cadherin. Fluorescence in situ hybridization was performed for fibroblast growth factor receptor 2. The median overall survival rates of the pregnancy-associated gastric cancer and control groups were 7.0 months and 15.0 months, respectively (p=0.189). Poor prognostic factors included advanced stage and tumor location in the corpus or the entire stomach but not pregnancy status or loss of E-cadherin. Pregnancy-associated gastric cancer was associated with a longer time from diagnosis to treatment (21 days vs 7 days, p=0.021). The two groups did not differ in the expression of the receptors or E-cadherin. The dismal prognosis of pregnancy-associated gastric cancer may related to the tumor stage and location rather than to pregnancy itself.
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影响因子：
6.4
作者：
PALLI, D;CIPRIANI, F;BUIATTI, E
通讯作者：
BUIATTI, E
影响因子：
3.7
作者：
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影响因子：
3.5
作者：
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通讯作者：
Seruca, R
影响因子：
3.7
作者：
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通讯作者：
Noh, Sung Hoon
影响因子：
4.2
作者：
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Hirakawa, Kosei