Sedative and antiepileptic effects of Anthocephalus cadamba Roxb. in mice and rats.
Sedative and antiepileptic effects of Anthocephalus cadamba Roxb. in mice and rats.
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DOI：
10.4103/0253-7613.89829
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发表时间：
2011-11
影响因子：
2.4
通讯作者：
Thippeswamy BS
中科院分区：
文献类型：
--
作者：
Nagakannan P;Shivasharan BD;Veerapur VP;Thippeswamy BS
本研究旨在评价花椒树皮乙醇提取物(ACE)在不同动物模型上的镇静和抗癫痫作用。血管紧张素转换酶以三种剂量进行测试。100、200和400 mg/kg的P.O.采用氯胺酮诱导的小鼠睡眠时间模型，观察其镇静作用、睡眠开始时间和持续时间。采用抗惊厥模型(戊四氮、异烟肼和最大电休克惊厥)来评价其对无发作和全身性惊厥的保护作用。在PTZ和INH诱导的癫痫模型中，观察到阵挛发作的发生、紧张期延长和死亡时间。在MES模型中，观察紧张性后腿伸展持续时间和昏迷开始时间。血管紧张素转换酶显著增加氯胺酮诱导的睡眠时间。PTZ模型和异烟肼模型小鼠的阵挛惊厥潜伏期、紧张性延长潜伏期和死亡时间均较模型组显著延长(P<0.001)，而MES模型小剂量组较高剂量组(200 mg/kg和400 mg/kg，P<0.05)效果显著。本研究结果表明，ACE具有镇静和抗癫痫作用。
The aim of the present study was to evaluate the sedative and antiepileptic activities of ethanolic extract of Anthocephalus cadamba (ACE) bark in various experimental animal models. ACE was tested at three doses viz. 100, 200 and 400 mg/kg p.o. We used ketamine-induced sleeping time model to test the sedative property of the extract where, onset and duration of sleep were observed. A paradigm of anticonvulsant models (pentylenetetrazole, isoniazid and maximal electroshock-induced seizures) were used to evaluate its protective effect against absence and generalized types of seizures. Onset of clonic convulsions, tonic extension and time of death were observed in PTZ and INH-induced seizure models. In MES model, duration of tonic hind leg extension and onset of stupor were observed. ACE showed significant increase in ketamine induced sleeping time. It also exhibited significant increase (P<0.05, 0.01 and 0.001) in latency to clonic convulsion, tonic extension and time of death in PTZ and INH models at all tested doses, whereas in the MES model, the lower dose was found to be effective when compared with the higher doses (200 and 400 mg/kg, p.o.). The results of the present investigation demonstrated that ACE possesses sedative and antiepileptic activities.
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影响因子：
7.9
作者：
Mahendran, S.;Thippeswamy, B. S.;Badami, S.
通讯作者：
Badami, S.
影响因子：
6.1
作者：
SANDRINI, M;MARRAMA, D;BERTOLINI, A
通讯作者：
BERTOLINI, A
影响因子：
7.3
作者：
Inan, S. Y.;Bueyuekafsar, K.
通讯作者：
Bueyuekafsar, K.
影响因子：
--
作者：
Kumar, Vishnu;Khan, Mohammad Mubin;Singh, Raj Kumar
通讯作者：
Singh, Raj Kumar
影响因子：
5.1
作者：
Ozbakis-Dengiz, Gunnur;Bakirci, Aysegul
通讯作者：
Bakirci, Aysegul