A specific phase of transcranial alternating current stimulation at the β frequency boosts repetitive paired-pulse TMS-induced plasticity.
A specific phase of transcranial alternating current stimulation at the β frequency boosts repetitive paired-pulse TMS-induced plasticity.
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β频率的经颅交流电刺激的特定阶段增强了重复的成对脉冲TM诱导的可塑性。
DOI：
10.1038/s41598-021-92768-x
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发表时间：
2021-06-23
影响因子：
4.6
通讯作者：
Tobimatsu S
中科院分区：
文献类型：
--
作者：
Nakazono H;Ogata K;Takeda A;Yamada E;Oka S;Tobimatsu S
经颅交流电刺激（tACS）在20 Hz（β）下与经颅磁刺激（TMS）以相位依赖的方式配对时，已被证明可调制运动诱发电位（MEP）。重复双脉冲TMS（rPPS）与I波周期性（1.5 ms）诱导短暂的MEP易化。我们假设tACS将以频率和相位依赖性方式调节rPPS的易化效应。为了检验我们的假设，我们研究了联合tACS和rPPS的影响。我们将rPPS与10 Hz（α）或β下的峰相或谷相tACS或假tACS（仅rPPS）联合应用。rPPS在假手术条件下的促进作用是暂时的，并且在参与者中是可变的。在β tACS峰值条件下，刺激后单脉冲MEP的显著增加持续超过30分钟，并且这种效应在参与者中是稳定的。相比之下，在波谷条件下，β tACS不调节MEP。此外，α tACS参数在干预后不影响单脉冲MEP。这些结果表明，rPPS诱导的跨突触功效的增加可以根据β tACS阶段而加强，并且该技术可以产生关于皮层兴奋性的持久可塑性。
Transcranial alternating current stimulation (tACS) at 20 Hz (β) has been shown to modulate motor evoked potentials (MEPs) when paired with transcranial magnetic stimulation (TMS) in a phase-dependent manner. Repetitive paired-pulse TMS (rPPS) with I-wave periodicity (1.5 ms) induced short-lived facilitation of MEPs. We hypothesized that tACS would modulate the facilitatory effects of rPPS in a frequency- and phase-dependent manner. To test our hypothesis, we investigated the effects of combined tACS and rPPS. We applied rPPS in combination with peak or trough phase tACS at 10 Hz (α) or β, or sham tACS (rPPS alone). The facilitatory effects of rPPS in the sham condition were temporary and variable among participants. In the β tACS peak condition, significant increases in single-pulse MEPs persisted for over 30 min after the stimulation, and this effect was stable across participants. In contrast, β tACS in the trough condition did not modulate MEPs. Further, α tACS parameters did not affect single-pulse MEPs after the intervention. These results suggest that a rPPS-induced increase in trans-synaptic efficacy could be strengthened depending on the β tACS phase, and that this technique could produce long-lasting plasticity with respect to cortical excitability.
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影响因子：
7.7
作者：
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通讯作者：
Fernandez-del-Olmo, Miguel
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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