Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder.
Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder.
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DOI：
10.1016/j.jpsychires.2012.11.002
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发表时间：
2013-03
影响因子：
4.8
通讯作者：
Watson, Stanley J.
中科院分区：
文献类型：
--
作者：
Medina, Adriana;Seasholtz, Audrey F.;Sharma, Vikram;Burke, Sharon;Bunney, William, Jr.;Myers, Richard M.;Schatzberg, Alan;Akil, Huda;Watson, Stanley J.
关键词：
大约50%的情绪障碍患者表现为高皮质醇血症。皮质醇通常通过与矿皮质激素受体（MR）和糖皮质激素受体（GR）结合在中枢神经系统中发挥其功能。MR和GR在人类海马中高度表达，一些研究表明，该区域MR或GR水平的改变可能导致重度抑郁症（MDD）的失调。研究还显示了海马的功能异质性，海马后部优先参与认知过程，而海马前部优先参与压力、情绪和情感。因此，我们假设对照组和MDD患者海马中GR和MR的表达不仅随疾病而变化，而且沿前/后轴具有区域特异性。学生t检验分析显示，与对照组相比，MDD组海马前部MR表达下降，但海马后部没有MR表达，GR无显著变化。线性回归分析显示，海马后部MR:GR相关性在自杀和非自杀患者之间有显著差异。我们的研究结果与之前关于海马皮质类固醇受体失调在情绪障碍中的报道一致，但通过分析海马的前/后轴扩展了这些发现。MDD患者海马前区而非后区MR降低，强调了海马前区在人类神经内分泌调节中的重要功能作用。
Approximately 50% of mood disorder patients exhibit hypercortisolism. Cortisol normally exerts its functions in the CNS via binding to mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). Both MR and GR are highly expressed in human hippocampus and several studies have suggested that alterations in the levels of MR or GR within this region may contribute to the dysregulation in major depressive disorder (MDD). Studies have also shown functional heterogeneity across the hippocampus, with posterior hippocampus preferentially involved in cognitive processes and anterior hippocampus involved in stress, emotion and affect. We therefore hypothesize that GR and MR expression in hippocampus of control and MDD patients may vary not only with disease, but also with regional specificity along the anterior/posterior axis. Student’s t-test analysis showed decreased expression of MR in the MDD group compared to controls in the anterior, but not the posterior hippocampus, with no significant changes in GR. Linear regression analysis showed a marked difference in MR:GR correlation between suicide and non-suicide patients in the posterior hippocampus. Our findings are consistent with previous reports of hippocampal corticosteroid receptor dysregulation in mood disorders, but extend those findings by analysis across the anterior/posterior axis of the hippocampus. A decrease in MR in the anterior but not posterior hippocampus of MDD patients emphasizes the important functional role of the anterior hippocampus in neuroendocrine regulation in humans.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
4.8
作者：
Klok, Melanie D.;Alt, Simone R.;DeRijk, Roel H.
通讯作者：
DeRijk, Roel H.
影响因子：
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作者：
López, JF;Chalmers, DT;Watson, SJ
通讯作者：
Watson, SJ
影响因子：
2.5
作者：
Colombo, M;Fernandez, T;Gross, CG
通讯作者：
Gross, CG
影响因子：
2.9
作者：
HERMAN, JP;CULLINAN, WE;WATSON, SJ
通讯作者：
WATSON, SJ