Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.
Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.
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山楂叶黄酮类化合物通过增强脂联素/AMPK途径缓解非酒精性脂肪肝。
DOI：
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发表时间：
2015-10
影响因子：
0.1
通讯作者：
Ji, Guang
中科院分区：
文献类型：
--
作者：
Shen, Hongyi;Yang, Lili;Zhang, Li;Ji, Guang
山楂（Hawthorn）为蔷薇科（Rosaceae）山楂属（Hawthorn）植物。山楂叶，是用于调味品和药用目的，以预防和治疗代谢功能障碍，如高血脂症，高血压和心血管疾病，在传统的中医。然而，其对非酒精性脂肪性肝病（NAFLD）的影响仍不清楚。本研究旨在探讨山楂叶黄酮类化合物（HLF）对高脂饮食（HFD）诱导的肝脂肪变性的保护作用及其机制。HLF补充显著降低体重，肝重，肝/体重比，改善血清参数和肝功能障碍，并显着降低肝脏脂质蓄积HFD喂养大鼠。此外，HLF干预显着增加循环脂联素水平和上调脂联素受体的表达，特别是脂联素受体2（AdipoR 2）在肝脏中。此外，腺苷一磷酸（AMP）激活的蛋白激酶（AMPK）也被激活，以及AMPK介导的固醇调节元件结合蛋白-1c（SREBP-1c）、过氧化物酶体增殖物激活受体α（PPARα）及其下游靶点的改变。总之，我们的数据表明，HLF改善肝脂肪变性，通过增强脂联素/AMPK途径在HFD诱导的NAFLD大鼠的肝脏。
Hawthorn (Crataeguspinnatifida) belongs to the genus Rosaceae family of plants. The hawthorn leaf, Crataeguspinnatifida Bunge, is used for both condiment and medicinal purposes to prevent and treat metabolic dysfunctions, such as hyperlipidemia, hypertension, and cardiovascular disease in traditional Chinese medicine. However, its effects on nonalcoholic fatty liver disease (NAFLD) remain obscure. The purpose of the present study was to investigate the protective effect of hawthorn leaf flavonoids (HLF), the dominant bioactive extracts of hawthorn leaves, on high fat diet (HFD)-induced hepatic steatosis and to elucidate its underlying mechanisms. HLF supplementation significantly lowered body weight, liver weight, liver/body weight ratio, improved serum parameters and liver dysfunction and markedly decreased hepatic lipid accumulation in HFD-fed rats. In addition, HLF intervention dramatically increased circulating adiponectin levels and up-regulated the expression of adiponectin receptors, particularly adiponectin receptor 2 (AdipoR2) in the liver. Moreover, adenosine monophosphate (AMP)-activated protein kinase (AMPK) was also activated, as well as AMPK-mediated alteration of sterol regulatory element binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor α (PPARα) and their downstream targets. Taken together, our data suggest that HLF ameliorates hepatic steatosis by enhancing the adiponectin/AMPK pathway in the liver of HFD-induced NAFLD rats.
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影响因子：
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作者：
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作者：
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DOI：
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DOI：
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发表时间：
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E. Smolle;S. Kessler;Nicole Golob;J. Haybaeck