Autistic characteristics in youth with anorexia nervosa before and after treatment.
Autistic characteristics in youth with anorexia nervosa before and after treatment.
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DOI：
10.1002/erv.2937
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发表时间：
2022-09
影响因子：
5.3
通讯作者：
Timko, C. Alix
中科院分区：
文献类型：
--
作者：
Susanin, Annabel;Cooper, Marita;Makara, Amanda;Kuschner, Emily S.;Timko, C. Alix
自闭症患者常见的认知特征经常出现在患有神经性厌食症（AN）的成年人中，这就提出了一个问题，即自闭症患者和AN患者是否可能共享一个内在表型。我们需要在AN的早期阶段检查自闭症特征，以准确地解析由于长期疾病而导致的行为改变的真实症状共现。我们进行了一项事后分析，研究了59名青少年与AN的自闭症特征。参与AN随机临床试验的青少年和父母在基线和治疗结束时完成了调查问卷，以探讨自闭症特征。我们使用自闭症概率指数（API）和自闭症谱系商-10将参与者分类为高于或低于自闭症临床指标的截止值。高度自闭症特征的比率在0-36%之间，这取决于所使用的仪器和数据是如何获得的（即，举报人举报或自我举报）。治疗完成者与未完成者之间的自闭症特征的父亲报告不同，母亲报告表明具有升高特征的患者体重增加较低。自闭症的低发病率和治疗期间自闭症特征的波动强调了对AN青少年自闭症特征进行纵向检查的重要性。未来的研究需要在更大的青少年样本中复制研究结果。
Cognitive characteristics common to autistic individuals are often seen in adults with anorexia nervosa (AN), raising the question of whether autistic people and people with AN may share an endophenotype. We need to examine autistic characteristics during the early stages of AN to accurately parse true symptom co-occurrence from behavioral alterations due to prolonged illness. We conducted a post-hoc analysis examining autistic characteristics in 59 youth with AN. Adolescents and parents participating in a randomized-clinical trial for AN completed questionnaires probing autistic characteristics at baseline and treatment end. We categorized participants as above or below cut-offs of clinical indicators of autism using the Autism Probability Index (API) and the Autism Spectrum Quotient-10. Rates of high autistic characteristics ranged between 0-36% depending on the instrument used and how the data was obtained (i.e., by informant report or self-report). Paternal report of autistic characteristics differed across treatment completers versus non completers and maternal report indicated lower weight gain for those with elevated characteristics. Low rates of autism and fluctuations in autistic features during treatment underscore the importance of longitudinal examinations of autistic characteristics in adolescents with AN. Future studies need to replicate findings in a larger adolescent sample.
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影响因子：
6.2
作者：
Rhind C;Bonfioli E;Hibbs R;Goddard E;Macdonald P;Gowers S;Schmidt U;Tchanturia K;Micali N;Treasure J
通讯作者：
Treasure J
影响因子：
2.1
作者：
Inoue T;Otani R;Iguchi T;Ishii R;Uchida S;Okada A;Kitayama S;Koyanagi K;Suzuki Y;Suzuki Y;Sumi Y;Takamiya S;Tsurumaru Y;Nagamitsu S;Fukai Y;Fujii C;Matsuoka M;Iwanami J;Wakabayashi A;Sakuta R
通讯作者：
Sakuta R
影响因子：
4.1
作者：
Carter, JC;Stewart, DA;Fairburn, CG
通讯作者：
Fairburn, CG
影响因子：
11.3
作者：
Boltri, Margherita;Sapuppo, Walter
通讯作者：
Sapuppo, Walter
一种新的、对发育敏感的体重抑制措施。
影响因子：
5.4
作者：
Singh S;Apple DE;Zhang F;Niu X;Lowe MR
通讯作者：
Lowe MR