Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
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自闭症儿童的母亲：血浆催产素和精氨酸加压素水平较低，而睾酮水平较高
DOI：
10.1371/journal.pone.0074849
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Han JS
中科院分区：
文献类型：
--
作者：
Xu XJ;Shou XJ;Li J;Jia MX;Zhang JS;Guo Y;Wei QY;Zhang XT;Han SP;Zhang R;Han JS
背景自闭症是一种普遍存在的神经发育障碍，被认为是遗传和环境风险因素共同作用的结果。据报道，自闭症儿童的母亲有一些类似自闭症的特征。我们推测，在自闭症儿童身上发现的催产素(OXT)、精氨酸加压素(AVP)和性激素调节失调可能也存在于他们的母亲身上。方法采用酶免疫法和放射免疫法分别测定孤独症患儿和正常儿童母亲血浆OXT(40例)、AVP(40例)和性激素(61例)水平，并探讨其与儿童孤独症行为评分(儿童孤独症评定量表(CARS)和孤独症行为量表(ABC))的关系。结果与对照组相比，自闭症儿童母亲的血浆OXT(p<；0.001)和AVP(p<；0.001)浓度显著降低，而血浆睾酮(p<；0.001)水平显著升高。儿童孤独症行为评分与母体血浆OXT、AVP水平呈负相关。结论孤独症儿童母亲体内存在OXT、AVP和/或睾酮系统的失调，可能影响儿童对孤独症的易感性。
Background Autism is a pervasive neurodevelopmental disorder,thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers. Methods We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children’s autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)). Results Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children’s autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP. Conclusions These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children’s susceptibility to autism.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
4
作者：
Auyeung, Bonnie;Baron-Cohen, Simon;Hackett, Gerald
通讯作者：
Hackett, Gerald