One-year test-retest reliability of intrinsic connectivity network fMRI in older adults.

One-year test-retest reliability of intrinsic connectivity network fMRI in older adults.
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DOI:
10.1016/j.neuroimage.2012.03.027
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发表时间:
2012-07-16
期刊:
影响因子:
5.7
通讯作者:
Seeley, William W.
Seeley, William W.
中科院分区:
医学1区
文献类型:
--
作者:
Guo, Christine C.;Kurth, Florian;Zhou, Juan;Mayer, Emeran A.;Eickhoff, Simon B.;Kramer, Joel H.;Seeley, William W.

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“Resting-state” or task-free fMRI can assess intrinsic connectivity network (ICN) integrity in health and disease, suggesting a potential for use of these methods as disease-monitoring biomarkers. Numerous analytical options are available, including model-driven ROI-based correlation analysis and model-free, independent component analysis (ICA). High test-retest reliability will be a necessary feature of a successful ICN biomarker, yet available reliability data remains limited. Here, we examined ICN fMRI test-retest reliability in 24 healthy older subjects scanned roughly one year apart. We focused on the salience network, a disease-relevant ICN not previously subjected to reliability analysis. Most ICN analytical methods proved reliable (intraclass coefficients > 0.4) and could be further improved by wavelet analysis. Seed-based ROI correlation analysis showed high map-wise reliability, whereas graph theoretical measures and temporal concatenation group ICA produced the most reliable individual unit-wise outcomes. Including global signal regression in ROI-based correlation analyses reduced reliability. Our study provides a direct comparison between the most commonly used ICN fMRI methods and potential guidelines for measuring intrinsic connectivity in aging control and patient populations over time.
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