HIstome--a relational knowledgebase of human histone proteins and histone modifying enzymes.
HIstome--a relational knowledgebase of human histone proteins and histone modifying enzymes.
复制标题
DOI：
10.1093/nar/gkr1125
复制
发表时间：
2012-01
影响因子：
14.9
通讯作者：
Galande S
中科院分区：
文献类型：
--
作者：
Khare SP;Habib F;Sharma R;Gadewal N;Gupta S;Galande S
组蛋白是一种丰富的核蛋白，是将真核DNA包装到染色体中所必需的。不同的组蛋白变体与它们的修饰密码结合在一起，控制着不同细胞过程中基因表达的调节。在过去的十年中，已经发现了几种催化添加和移除多种组蛋白修饰的酶，使得研究它们在正常细胞过程和各种病理条件中的作用成为可能(S)。然而，这种突然涌入的数据需要一个最新的知识库，以一种易于访问的格式汇编、组织和向用户提供经过策划的科学信息。在这里，我们介绍HIstome，一个可浏览的，手动管理的关系数据库，提供关于人组蛋白及其修饰位置、变体和修饰酶的信息。HIstome是关于55个人类组蛋白、106个不同的翻译后修饰(PTM)位点和152个组蛋白修饰酶的知识库。条目被分成5种类型的组蛋白、8种类型的翻译后修饰和14种催化这些修饰的添加和移除的酶。该资源将对表观遗传学家、药理学家和临床医生有用。HIstome：组蛋白信息库可在http://www.iiserpune.ac.in/Coee/Organome/和http://www.actrec.gov.in/histome/.∼网站上找到
Histones are abundant nuclear proteins that are essential for the packaging of eukaryotic DNA into chromosomes. Different histone variants, in combination with their modification ‘code’, control regulation of gene expression in diverse cellular processes. Several enzymes that catalyze the addition and removal of multiple histone modifications have been discovered in the past decade, enabling investigations of their role(s) in normal cellular processes and diverse pathological conditions. This sudden influx of data, however, has resulted in need of an updated knowledgebase that compiles, organizes and presents curated scientific information to the user in an easily accessible format. Here, we present HIstome, a browsable, manually curated, relational database that provides information about human histone proteins, their sites of modifications, variants and modifying enzymes. HIstome is a knowledgebase of 55 human histone proteins, 106 distinct sites of their post-translational modifications (PTMs) and 152 histone-modifying enzymes. Entries have been grouped into 5 types of histones, 8 types of post-translational modifications and 14 types of enzymes that catalyze addition and removal of these modifications. The resource will be useful for epigeneticists, pharmacologists and clinicians. HIstome: The Histone Infobase is available online at http://www.iiserpune.ac.in/∼coee/histome/ and http://www.actrec.gov.in/histome/.
登录
查看更多内容
影响因子：
7
作者：
Huang, Hailiang;Maertens, Alexandra M.;Bader, Joel S.
通讯作者：
Bader, Joel S.
影响因子：
2.9
作者：
Mari単o-Ramirez, L;Hsu, B;Landsman, D
通讯作者：
Landsman, D
影响因子：
5.8
作者：
O'Connor, Timothy R.;Wyrick, John J.
通讯作者：
Wyrick, John J.
DOI：
10.1126/science.1191078
发表时间：
2010-10-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bonasio R;Tu S;Reinberg D
通讯作者：
Reinberg D
影响因子：
3.2
作者：
Oliver, Samuel S.;Denu, John M.
通讯作者：
Denu, John M.