Increased risk of COVID-19 mortality rate in IFITM3 rs6598045 G allele carriers infected by SARS-CoV-2 delta variant.
Increased risk of COVID-19 mortality rate in IFITM3 rs6598045 G allele carriers infected by SARS-CoV-2 delta variant.
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DOI：
10.1186/s40246-022-00434-8
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发表时间：
2022-11-19
期刊：
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
干扰素诱导的跨膜蛋白3（IFITM 3）是免疫系统防御病毒感染的重要组成部分。IFITM 3基因的变异与表达变化和2019年严重冠状病毒病（COVID-19）的风险有关。本研究旨在调查IFITM 3 rs6598045、定量聚合酶链反应（qPCR）循环阈值（Ct）值和严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）变体是否与COVID-19死亡率增加相关。采用扩增难治性突变系统-聚合酶链反应（PCR）技术对1342例SARS冠状病毒2型（SARS-CoV-2）阳性康复者和1149例SARS冠状病毒2型（SARS-CoV-2）阳性死亡者的IFITM 3基因rs6598045多态性进行基因分型。IFITM 3 rs6598045 G等位基因在死亡患者中的频率显著高于恢复者。此外，在Delta变体中观察到最高死亡率和最低qPCR Ct值。COVID-19死亡率与δ变体中的IFITM 3 rs6598045 GG和AG以及α变体中的IFITM 3 rs6598045 AG相关。GG和AG基因型个体与AA基因型个体之间的qPCR Ct值存在统计学显著差异。观察到COVID-19的死亡率、IFITM 3 rs6598045的G等位基因和SARS-CoV-2变异体之间可能存在相关性。然而，仍然需要大规模的研究来验证我们的结果。在线版本包含补充材料，可通过10.1186/s40246-022-00434-8获得。
The interferon-induced transmembrane-protein 3 (IFITM3) is a vital component of the immune system's defense against viral infection. Variants in the IFITM3 gene have been linked to changes in expression and the risk of severe Coronavirus disease 2019 (COVID-19). This study aimed to investigate whether IFITM3 rs6598045, quantitative polymerase chain reaction (qPCR) cycle threshold (Ct) values, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are associated with an increased mortality rate of COVID-19. The genotyping of IFITM3 rs6598045 polymorphism was analyzed using the amplification refractory mutation system-polymerase chain reaction in 1342 recovered and 1149 deceased patients positive for SARS-CoV-2. In this study, IFITM3 rs6598045 G allele as minor allele frequency was significantly more common in the deceased patients than in the recovered ones. Furthermore, the highest mortality rates were observed in Delta variant and lowest qPCR Ct values. COVID-19 mortality was associated with IFITM3 rs6598045 GG and AG in Delta variant and IFITM3 rs6598045 AG in Alpha variant. A statistically significant difference was observed in the qPCR Ct values between individuals with GG and AG genotypes and those with an AA genotype. A possible correlation was observed between the mortality rate of COVID-19, the G allele of IFITM3 rs6598045, and SARS-CoV-2 variants. However, large-scale research is still required to validate our results. The online version contains supplementary material available at 10.1186/s40246-022-00434-8.
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影响因子：
4.1
作者：
Engelmann I;Alidjinou EK;Ogiez J;Pagneux Q;Miloudi S;Benhalima I;Ouafi M;Sane F;Hober D;Roussel A;Cambillau C;Devos D;Boukherroub R;Szunerits S
通讯作者：
Szunerits S
影响因子：
4.5
作者：
Raheem Juhi Al-Kaabi, Nidhal;Khameneh, Sepideh Chodari;Montazeri, Mohadeseh;Mardasi, Mahsa;Amroabadi, Jalal Mosayebi;Sakhaee, Fatemeh;Fateh, Abolfazl
通讯作者：
Fateh, Abolfazl
影响因子：
7.3
作者：
Abdelrahman Z;Li M;Wang X
通讯作者：
Wang X
影响因子：
5.6
作者：
Tomaszewska A;Rustecka A;Lipińska-Opałka A;Piprek RP;Kloc M;Kalicki B;Kubiak JZ
通讯作者：
Kubiak JZ
影响因子：
11.3
作者：
Bailey CC;Zhong G;Huang IC;Farzan M
通讯作者：
Farzan M