Flexible, scalable, high channel count stereo-electrode for recording in the human brain.
Flexible, scalable, high channel count stereo-electrode for recording in the human brain.
复制标题
灵活的，可扩展的，高通道计数立体电极记录在人脑。
DOI：
10.1038/s41467-023-43727-9
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发表时间：
2024-01-17
影响因子：
16.6
通讯作者：
Dayeh, Shadi. A.
中科院分区：
文献类型：
--
作者：
Lee, Keundong;Paulk, Angelique C.;Ro, Yun Goo;Cleary, Daniel R.;Tonsfeldt, Karen J.;Kfir, Yoav;Pezaris, John S.;Tchoe, Youngbin;Lee, Jihwan;Bourhis, Andrew M.;Vatsyayan, Ritwik;Martin, Joel R.;Russman, Samantha M.;Yang, Jimmy C.;Baohan, Amy;Richardson, R. Mark;Williams, Ziv M.;Fried, Shelley I.;Sang, U. Hoi;Raslan, Ahmed M.;Ben-Haim, Sharona;Halgren, Eric;Cash, Sydney S.;Dayeh, Shadi. A.
在过去的十年里，立体定向放置的电极已经成为脑深部记录和刺激各种神经和精神疾病的黄金标准。然而，目前的电极在空间分辨率和记录小群体神经元的能力上都是有限的，更不用说单个神经元了。在这里，我们报告了一种创新的，可定制的，单片集成的人类级柔性深度电极，能够记录多达128个通道，并能够在脑组织中记录10厘米的深度。这种薄的、样式引导的深度电极能够记录局部场电位和单个神经元活动（动作电位），并在不同物种之间进行验证。该设备代表了制造和设计方法的进步，扩展了临床神经病学主流技术的能力。用于深部脑记录和刺激的电极有许多局限性。在这里，作者描述了一种薄膜深度电极，可以为记录大脑活动提供更好的空间和时间分辨率。
Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology. Electrodes available for deep brain recording and stimulation have a number of limitations. Here the authors describe a thin-film depth electrode that may offer improved spatial and temporal resolution for recording brain activity.
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影响因子：
3
作者：
Westover, M. Brandon;Shafi, Mouhsin M.;Ching, ShiNung;Chemali, Jessica J.;Purdon, Patrick L.;Cash, Sydney S.;Brown, Emery N.
通讯作者：
Brown, Emery N.
影响因子：
19
作者：
Ganji, Mehran;Kaestner, Erik;Dayeh, Shadi A.
通讯作者：
Dayeh, Shadi A.
影响因子：
--
作者：
Bronstein JM;Tagliati M;Alterman RL;Lozano AM;Volkmann J;Stefani A;Horak FB;Okun MS;Foote KD;Krack P;Pahwa R;Henderson JM;Hariz MI;Bakay RA;Rezai A;Marks WJ Jr;Moro E;Vitek JL;Weaver FM;Gross RE;DeLong MR
通讯作者：
DeLong MR
影响因子：
16.2
作者：
Chung, Jason E.;Sellers, Kristin K.;Chang, Edward F.
通讯作者：
Chang, Edward F.
影响因子：
4.6
作者：
Cui, XY;Martin, DC
通讯作者：
Martin, DC