Biosynthesis of lung lipids from acetoacetate and glucose in the developing rat in vivo.

Biosynthesis of lung lipids from acetoacetate and glucose in the developing rat in vivo.
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发育中的大鼠体内乙酰乙酸和葡萄糖生物合成肺脂质。

DOI:
10.1016/0020-711x(82)90147-1
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发表时间:
1982
期刊:
The International journal of biochemistry
影响因子:
--
通讯作者:
Yeh,YY
Yeh,YY
中科院分区:
--
文献类型:
--
作者:
Yeh,YY

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1.在哺乳期,给予大鼠的[3- 14 C]乙酰乙酸酯和[U-14 C]葡萄糖易于用于肺中磷脂、胆固醇和甘油酯的合成。2.在合成的所有脂质中,磷脂酰胆碱占[14 C]乙酰乙酸酯的31-48%和[14 C]葡萄糖的30-46%。合成的磷脂酰胆碱主要含有[14 C]-标记的棕榈酸酯。3.甘油脂质分别占由[14 C]葡萄糖和[14 C]乙酰乙酸合成的总脂质的83-92%和56-68%。4.葡萄糖是甘油酯-甘油的优选底物,而乙酰乙酸似乎更适合脂肪酸和胆固醇合成。
1.[3-14C] Acetoacetate and [U-14C] glucose administered to rats were readily utilized for synthesis of phospholipids, cholesterol and glycerides in the lung during suckling period. 2. Among all lipids synthesized, phosphatidylcholine accounted for 31-48% from [14C] acetoacetate and 30-46% from [14C] glucose. The synthesized phosphatidylcholine contained predominantly [14C]-labeled palmitate. 3. Glycerol lipids represented 83-92% and 56-68% of total lipids synthesized from [14C] glucose and [14C] acetoacetate, respectively. 4. Glucose is the preferred substrate for glyceride-glycerol, while acetoacetate appears better for fatty acid and cholesterol synthesis.
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发表时间: 1971
影响因子: --
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