The effects of postmenopausal hormone therapy on serum estrogen, progesterone, and sex hormone-binding globulin levels in healthy postmenopausal women.
The effects of postmenopausal hormone therapy on serum estrogen, progesterone, and sex hormone-binding globulin levels in healthy postmenopausal women.
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DOI：
10.1097/gme.0b013e3181cb49e9
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Anderson G
中科院分区：
文献类型：
--
作者：
Edlefsen KL;Jackson RD;Prentice RL;Janssen I;Rajkovic A;O'Sullivan MJ;Anderson G
激素治疗（HT）的使用者和非使用者之间以及单独使用雌激素（ET）和雌激素加孕激素治疗（EPT）的使用者之间疾病结局的差异可能与这些人群之间血清激素浓度的差异有关。在这项研究中，我们研究了健康的绝经后妇女在一年的HT后血清激素水平的反应。从妇女健康倡议的活性组和安慰剂组的200名健康依从参与者中选择一个代表性子样本，ET（结合马雌激素0.625 mg每日）或EPT（ET+醋酸甲羟孕酮2.5 mg每日）的随机对照临床试验，用于测定基线和随机化后一年的选定性激素水平。与安慰剂相比，在接受积极ET干预的参与者中，雌激素水平从基线到第1年增加了3.6倍（总雌酮），2.7倍（总雌二醇），1.8倍（生物利用度和游离雌二醇浓度）。血清SHBG浓度也增加了2.5倍。相反，服用外源性EPT的妇女孕酮水平略有下降。血清雌激素和SHBG的反应没有显着不同的加入孕酮。在亚组分析中，激素反应因年龄、种族、BMI、吸烟、血管痉挛症状和基线激素水平而异。这些数据提供了血清激素对HT的反应的参考点，并证明血清雌激素对ET和EPT的反应相似。EPT治疗后血清孕酮水平轻微下降的意义尚不确定。确定了雌激素的潜在治疗相互作用，这表明内源性激素水平低的女性对HT的反应更大。
Differences in disease outcomes between users and non-users of hormone therapy (HT) and between users of estrogen alone (ET) and users of estrogen plus progesterone therapy (EPT) may relate to differences in serum hormone concentrations between these populations. In this study, we examine the response of serum hormone levels in healthy post-menopausal women after one year of HT. A representative sub-sample of 200 healthy adherent participants from the active and placebo groups of the Women's Health Initiative randomized, controlled clinical trials of ET (conjugated equine estrogen 0.625 mg daily) or EPT (ET plus medroxyprogesterone actetate 2.5 mg daily) were selected for determination of selected sex hormone levels at baseline and one year after randomization. In participants receiving active ET intervention compared to placebo, estrogenic hormone levels increased from baseline to year 1 by 3.6-fold for total estrone, 2.7-fold for total estradiol, and 1.8-fold for bioavailable and free estradiol concentrations. Serum SHBG concentrations also increased 2.5-fold. In contrast, progesterone levels decreased slightly in women taking exogenous EPT. The response of serum estrogens and SHBG did not differ substantially with the addition of progesterone. In subgroup analyses, hormone response varied by age, ethnicity, BMI, smoking, vasomotor symptoms, and baseline hormone levels. These data provide a reference point for the serum hormone response to HT, and demonstrate that response of serum estrogens is similar for ET and EPT. The implications of the slight decrease in serum progesterone levels with EPT therapy are uncertain. Potential treatment interactions for estrogenic hormones were identified, which suggest a larger response to HT in women with low endogenous levels.
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影响因子：
2.8
作者：
Ausmanas, M. K.;Tan, D. A.;Holinka, C. F.
通讯作者：
Holinka, C. F.
影响因子：
5.8
作者：
Randolph, JF;Sowers, MF;Matthews, KA
通讯作者：
Matthews, KA
DOI：
10.1034/j.1600-0412.1999.780714.x
发表时间：
1999-08-01
影响因子：
4.3
作者：
Overlie, I;Moen, MH;Holte, A
通讯作者：
Holte, A
影响因子：
7.2
作者：
Casson, PR;ElkindHirsch, KE;Snabes, MC
通讯作者：
Snabes, MC
影响因子：
5.6
作者：
Stefanick, ML;Cochrane, BB;Johnson, SR
通讯作者：
Johnson, SR