Principles for Guiding the Selection of Early Childhood Neurodevelopmental Risk and Resilience Measures: HEALthy Brain and Child Development Study as an Exemplar.
Principles for Guiding the Selection of Early Childhood Neurodevelopmental Risk and Resilience Measures: HEALthy Brain and Child Development Study as an Exemplar.
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DOI：
10.1007/s42844-020-00025-3
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Johnson SP
中科院分区：
文献类型：
--
作者：
Morris AS;Wakschlag L;Krogh-Jespersen S;Fox N;Planalp B;Perlman SB;Shuffrey LC;Smith B;Lorenzo NE;Amso D;Coles CD;Johnson SP
风险和弹性途径的发展起源的巨大个体差异与大数据科学的复杂能力相结合，越来越多地表明大型神经发育联盟必须捕捉人口异质性和发展轨迹的关键变化。与此同时，这种涉及多个独立站点的大规模基于人口的设计也必须权衡相互竞争的需求。例如，对有效的、可扩展的评估策略的需求必须与对细微差别的、发育敏感的表型分析的需求相平衡，这些表型分析针对与神经机制的联系以及常见和不同暴露途径的规范进行了优化。为此目的而设计的标准化流行病学组合，如PhenX（表型和eXposures的共识措施）和美国国立卫生研究院（NIH）的ESTA提供了良好的“现成”评估工具，这些工具经过充分验证，并使交叉研究具有可比性。然而，这些标准化的工具包也会限制随着时间的推移利用神经发育测量进步的能力，有时会不成比例地重复既定的测量。此外，单个联合体往往耗费大量精力“重新发明轮子”，这是效率低下的，无法充分发挥与其他类似举措的潜在协同作用。为了解决这些问题，本文提出了一个早期儿童神经发育评估策略，指导下的一套原则，综合发展和务实的考虑所产生的健康的大脑和儿童发展（HBCD）规划联盟的神经发育工作组。这些原则强调风险和风险促进过程的特征。提供了针对六溴环十二烷的具体测量建议，以说明其应用。然而，原则旨在作为一个指导框架，超越任何特定的倡议，作为一个广泛的神经发育知情，幼儿评估战略的大规模财团科学。
The vast individual differences in the developmental origins of risk and resilience pathways combined with sophisticated capabilities of big data science increasingly point to the imperative of large, neurodevelopmental consortia to capture population heterogeneity and key variations in developmental trajectories. At the same time, such large-scale population-based designs involving multiple independent sites also must weigh competing demands. For example, the need for efficient, scalable assessment strategies must be balanced with the need for nuanced, developmentally sensitive phenotyping optimized for linkage to neural mechanisms and specification of common and distinct exposure pathways. Standardized epidemiologic batteries designed for this purpose such as PhenX (consensus measures for Phenotypes and eXposures) and the National Institutes of Health (NIH) Toolbox provide excellent “off the shelf” assessment tools that are well-validated and enable cross-study comparability. However, these standardized toolkits can also constrain ability to leverage advances in neurodevelopmental measurement over time, at times disproportionately advantaging established measures. In addition, individual consortia often expend exhaustive effort “reinventing the wheel,” which is inefficient and fails to fully maximize potential synergies with other like initiatives. To address these issues, this paper lays forth an early childhood neurodevelopmental assessment strategy, guided by a set of principles synthesizing developmental and pragmatic considerations generated by the Neurodevelopmental Workgroup of the HEALthy Brain and Child Development (HBCD) Planning Consortium. These principles emphasize characterization of both risk- and resilience-promoting processes. Specific measurement recommendations to HBCD are provided to illustrate application. However, principles are intended as a guiding framework to transcend any particular initiative as a broad neurodevelopmentally informed, early childhood assessment strategy for large-scale consortia science.
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影响因子：
2.9
作者：
Clark CA;Espy KA;Wakschlag L
通讯作者：
Wakschlag L
DOI：
10.1016/j.jaac.2017.12.011
发表时间：
2018-03
影响因子：
13.3
作者：
Barch DM;Belden AC;Tillman R;Whalen D;Luby JL
通讯作者：
Luby JL
影响因子：
4
作者：
Buss, Kristin A.
通讯作者：
Buss, Kristin A.
影响因子：
4.7
作者：
Barch DM;Albaugh MD;Avenevoli S;Chang L;Clark DB;Glantz MD;Hudziak JJ;Jernigan TL;Tapert SF;Yurgelun-Todd D;Alia-Klein N;Potter AS;Paulus MP;Prouty D;Zucker RA;Sher KJ
通讯作者：
Sher KJ
影响因子：
3.6
作者：
Best, John R.;Miller, Patricia H.;Naglieri, Jack A.
通讯作者：
Naglieri, Jack A.