Timing and sequence of brain activity in top-down control of visual-spatial attention.
Timing and sequence of brain activity in top-down control of visual-spatial attention.
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DOI：
10.1371/journal.pbio.0050012
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发表时间：
2007-01
期刊：
影响因子：
9.8
通讯作者：
Woldorff MG
中科院分区：
文献类型：
--
作者：
Grent-'t-Jong T;Woldorff MG
最近使用功能性磁共振成像（fMRI）进行的脑成像研究表明，额叶-顶叶网络参与了自上而下的注意力控制。然而，人们对这个网络中激活的时间和顺序知之甚少。为了研究这些时间问题，我们使用了事件相关脑电位（ERP）和一个专门设计的视觉空间注意力提示范式，这是作为一个多方法的一部分，其中包括一个密切对应的事件相关的功能磁共振成像研究使用相同的范式。在第一个400毫秒后的线索，注意力导向和控制线索引起类似的一般线索处理活动，对应于更多的横向子区域的额顶叶网络与功能磁共振成像。在此之后，注意力引导线索引发了持续的负极性脑电波，而控制线索则没有。这种活动可能与更内侧的额顶叶亚区有关，这些亚区在功能磁共振成像中也被识别为专门参与注意力定向。重要的是，头皮ERP和fMRI种子源模型的定位相关活动表明，额叶与顶叶的贡献（10400与10700毫秒）的早期发病。随后（约800-900 ms），在特定区域的视觉-感觉枕叶皮层中进行前靶偏置活动。这些结果表明了注意力控制大脑网络关键组件的激活序列，为深入了解它们的功能角色提供了帮助。更具体地说，这些结果表明，自愿注意定向是由额叶皮层的内侧部分，然后招募内侧顶叶区。这些区域共同实现特定区域视觉感觉皮层的偏置，以促进对即将到来的视觉刺激的处理。注意力是一种基本的认知功能，它使我们能够将神经资源集中在我们环境中的事件或信息上，这些事件或信息在任何给定时刻对我们来说都是最重要或最有趣的。最近的功能性神经影像学研究表明，额叶和顶叶皮层中的大脑区域网络参与将我们的注意力引导到我们视野中的特定位置。然而，我们对这个注意力控制网络的各个部分的激活时间和顺序知之甚少，因此限制了我们对它们功能作用的理解。我们通过结合两种测量认知大脑活动的互补方法：功能性磁共振成像（fMRI）和脑电图（EEG），提取了注意力控制的神经机制的更精确的图像。功能磁共振成像提供的信息是毫米级的大脑活动的位置，而脑电图提供的是毫秒级的时间信息。我们的研究结果表明，视觉空间注意力控制是在额叶脑区，加入后不久，顶叶参与。这些大脑区域一起为视觉皮层中的相关区域做好准备，以便在所关注的空间区域中对视觉输入进行增强处理。结合这些方法揭示了额顶叶网络内神经激活的时间和顺序，并提供了控制人类视觉注意力的机制的更精确的图片。
Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electrical brain potentials (ERPs) and a specially designed visual-spatial attentional-cueing paradigm, which were applied as part of a multi-methodological approach that included a closely corresponding event-related fMRI study using an identical paradigm. In the first 400 ms post cue, attention-directing and control cues elicited similar general cue-processing activity, corresponding to the more lateral subregions of the frontal-parietal network identified with the fMRI. Following this, the attention-directing cues elicited a sustained negative-polarity brain wave that was absent for control cues. This activity could be linked to the more medial frontal–parietal subregions similarly identified in the fMRI as specifically involved in attentional orienting. Critically, both the scalp ERPs and the fMRI-seeded source modeling for this orienting-related activity indicated an earlier onset of frontal versus parietal contribution (∼400 versus ∼700 ms). This was then followed (∼800–900 ms) by pretarget biasing activity in the region-specific visual-sensory occipital cortex. These results indicate an activation sequence of key components of the attentional-control brain network, providing insight into their functional roles. More specifically, these results suggest that voluntary attentional orienting is initiated by medial portions of frontal cortex, which then recruit medial parietal areas. Together, these areas then implement biasing of region-specific visual-sensory cortex to facilitate the processing of upcoming visual stimuli. Attention is a fundamental cognitive function that allows us to focus neural resources on events or information in our environment that are most important or interesting to us at any given moment. Recent functional neuroimaging studies have indicated that a network of brain areas in frontal and parietal cortex is involved in directing our attention to specific locations in our visual field. However, little is known about the timing and sequence of activations within the various parts of this attentional control network, thus limiting our understanding of their functional roles. We extracted a more precise picture of the neural mechanisms of attentional control by combining two complementary methods of measuring cognitive brain activity: functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). fMRI offers information on a millimeter scale about the locations of brain activity, whereas EEG offers temporal information on a scale of milliseconds. Our results indicate that visual-spatial attentional control is initiated in frontal brain areas, joined shortly afterwards by parietal involvement. Together, these brain areas then prepare relevant areas in the visual cortex for performing enhanced processing of visual input in the attended region of space. A combination of methods reveals the timing and sequence of neural activation within the frontal-parietal network and provides a more precise picture of the mechanisms controlling visual attention in humans.
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影响因子：
2.5
作者：
Iidaka, T;Matsumoto, A;Sadato, N
通讯作者：
Sadato, N
影响因子：
5.7
作者：
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作者：
Han, SH;Jiang, Y;Zhai, RY
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影响因子：
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作者：
Busse, L;Woldorff, MG
通讯作者：
Woldorff, MG
DOI：
10.1037/0096-1523.14.2.188
发表时间：
1988-05-01
影响因子：
2.1
作者：
DOWNING, CJ
通讯作者：
DOWNING, CJ