Neuropeptide Y and sympathetic control of vascular tone in hypertension.
Neuropeptide Y and sympathetic control of vascular tone in hypertension.
复制标题
神经肽 Y 和交感神经对高血压血管张力的控制。
DOI：
10.1007/3-7643-7417-9_6
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Westfall,ThomasC
中科院分区：
文献类型：
--
作者：
Westfall,ThomasC
现在普遍认为交感神经表达多达三种神经递质：去甲肾上腺素（NE）、神经肽Y（NPY）和腺苷-5 '-三磷酸（ATP）[1-4]。这三种共递质存在的证据来自研究，研究表明它们位于交感神经中，它们可以在适当的条件下释放，每种共递质的应用模拟交感神经刺激的一个阶段，并且每个阶段都可以用适当的拮抗剂阻断。已知NPY与NE和ATP共定位于支配多种血管的血管周围神经中。NPY对递质的合成和释放具有连接前调节作用[5]。该肽还参与心血管调节机制。选择性NPY-Y1拮抗剂的研究提供了证据，表明产生直接收缩效应或增强其他血管活性物质收缩效应的主要连接后受体是Y1亚型。类似地，选择性Y2拮抗剂的研究表明，外周和中枢神经系统（CNS）中的主要连接前受体均为Y2亚型[5]。其他的NPY受体亚型也可能参与连接前和连接后的作用，虽然信息是不完整的，它似乎是公认的原发性高血压是一种多因素的疾病，涉及许多改变，在神经系统和内分泌系统以及血管平滑肌功能的改变。尽管导致高血压的病理生理机制性质复杂，但有大量证据表明，在各种实验性高血压模型以及人类高血压中，交感神经活动增加。
It is now well accepted that sympathetic nerves express as many as three neurotransmitters: norepinephrine (NE), neuropeptide Y (NPY) and adenosine-5'-triphosphate (ATP)[1–4]. Evidence for the existence of these three co-transmitters has come from studies showing that they are located in sympathetic nerves, that they can be released under appropriate conditions, that the application of each mimics a phase of sympathetic nerve stimulation, and that each phase can be blocked with an appropriate antagonist. NPY is known to be colocalized with NE and ATP in perivascular nerves innervating a variety of blood vessels. NPY exerts prejunctional modulatory effects on transmitter synthesis and release [5]. The peptide is also involved in cardiovascular regulatory mechanisms. Studies with selective NPY-Y1 antagonists provide evidence that the principal postjunctional receptor that produces direct contractile effects or potentiation of the contractile effects of other vasoactive substances is of the Y1 subtype. Similarly, studies with selective Y2 antagonists suggest that the principle prejunctional receptor is of the Y2 subtype, both in the periphery and central nervous system (CNS)[5]. Other NPY receptor subtypes may also be involved in the prejunctional and postjunctional actions of NPY although information is incomplete.It appears well accepted that essential hypertension is a multifactorial disease involving many alterations in the nervous system and endocrine system as well as alterations in vascular smooth muscle function. Despite the complex nature of the pathophysiological mechanisms contributing to hypertension, there is considerable evidence for an involvement of increased sympathetic nerve activity in various experimental hypertensive models as well as human hypertension [6–11].
登录
查看更多内容
神经肽 Y 的中枢心血管作用
影响因子：
4.9
作者：
M. Mcauley;Xiaoli Chen;T. Westfall
通讯作者：
T. Westfall
嗜铬细胞瘤患者血浆嗜铬粒蛋白 A B、神经肽 Y 和儿茶酚胺
影响因子：
11.1
作者：
S. Gröndal;B. Eriksson;B. Hamberger;E. Theodorsson
通讯作者：
E. Theodorsson
神经递质和神经肽在自发性高血压大鼠血压调节中的作用。
影响因子：
2.1
作者：
W. Louis;E. Conway;L. Howes;C. Maccarrone;P. Beart;B. Jarrott
通讯作者：
B. Jarrott
急性压力和长期血压升高：高血压的可能原因？
影响因子：
4.9
作者：
T. Unger;G. Parati
通讯作者：
G. Parati
大鼠醋酸去氧皮质酮盐高血压发生过程中神经肽Y样免疫反应性循环水平和心血管组织含量的变化
影响因子：
4.9
作者：
P. Moreau;J. de Champlain;N. Yamaguchi
通讯作者：
N. Yamaguchi