Associative learning is necessary for airborne pheromones to activate sexual arousal-linked brain areas of female rats
Associative learning is necessary for airborne pheromones to activate sexual arousal-linked brain areas of female rats
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联想学习对于空气中的信息素激活雌性大鼠与性唤起相关的大脑区域是必要的
DOI：
10.1007/s00265-019-2685-9
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发表时间：
2019-06
影响因子：
2.3
通讯作者：
Jianxu Zhang
中科院分区：
文献类型：
--
作者：
Yao-Hua Zhang;Ming-Ming Tang;Xiao Guo;Xiao-Rong Gao;Jianxu Zhang
啮齿类动物尿中的雄性信息素包括挥发性有机化合物（VOCs）和主要尿蛋白（MUP）。在一些研究中，据报道，在小鼠中，雌性对雄性气味的吸引力是通过与MUP的联想学习获得的。在这里，我们发现，VOC和MUP性信息素在大鼠在8周龄左右分化，断奶时与雄性分开的雌性在性成熟后对雄性尿味没有偏好。嗅觉偏好，可以获得在女性反复经验的VOC信息素单独以及男性尿液或合成VOC信息素和重组MUP的混合物。然而，通过神经免疫组织化学研究进一步揭示了获得性嗅觉偏好男性尿液的差异。共混物表现出神经激活的主要嗅觉系统（MOS），辅助系统（AOS），和腹内侧下丘脑（VMH），表明性唤起，而VOC单独只引起神经激活的MOS。我们认为，嗅觉偏好是通过重复的经验，无论是挥发性有机化合物或挥发性有机化合物和MUP的混合物产生的，但与性唤起相关的神经激活必须通过与MUP的联想学习获得在雌性rates.Significance statementWhen成年雌性大鼠在成熟前与男性分开，他们失去了吸引力的男性尿液气味。雌性对雄性尿液中挥发性信息素和蛋白质信息素的重复体验可以获得雌性对挥发性信息素的偏好。与性唤起相关的大脑区域被男性尿液激活的女性与挥发性有机化合物的经验与MUP，但没有在那些经验丰富的挥发性有机化合物单独。VOC和MUP信息素之间的关联学习是必要的男性尿气味诱导的FOS反应的关键区域的性唤起/兴奋的雌性大鼠。
AbstractIn rodents, urine-borne male pheromones include volatile organic compounds (VOCs) and major urinary proteins (MUPs). In mice, the attraction of females to male odor is reportedly acquired through associative learning with MUPs in some studies. Here, we found that VOC and MUP sex pheromones were differentiated in rats at around 8 weeks of age and that females separated from males at weaning showed no preference for male urine odor after sexual maturity. Olfactory preferences could be gained in females after repeated experience of VOC pheromones alone as well as male urine or a blend of synthetic VOC pheromones and recombinant MUPs. However, differences in acquired olfactory preferences for male urine were further revealed by neuro-immuno-histochemical studies. The blend exhibited neural activation in the main olfactory system (MOS), accessory system (AOS), and the ventromedial hypothalamus (VMH), indicating sexual arousal, whereas the VOC alone only caused neural activation of MOS. We suggest that olfactory preference is generated through repeated experience of either VOCs or a blend of VOCs and MUPs, but the neural activations related to sexual arousal have to be acquired through associative learning with MUPs in female rats.Significance statementWhen adult female rats were separated from males before maturity, they lost their attraction to male urine odor. Female preference to volatiles in male urine could be gained by repeated experience of volatile and protein pheromones. Brain regions related to sexual arousal were activated by male urine in females with experience of VOCs together with MUPs but not in those experienced with VOCs alone. Associative learning between VOC and MUP pheromones is necessary for male urine odor-induced FOS responses in the key regions for sexual arousal/excitement in female rats.
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影响大鼠性别和性腺的气味化合物和 3 种雄性信息素
影响因子：
3.5
作者：
Zhang JX;Sun L;Zhang JH;Feng ZY
通讯作者：
Feng ZY
影响因子：
2.9
作者：
P. Romero;C. Beltramino;H. Carrer
通讯作者：
P. Romero;C. Beltramino;H. Carrer
影响因子：
3.9
作者：
Novotny, MV
通讯作者：
Novotny, MV
DOI：
10.1007/978-1-4613-2235-1_36
发表时间：
1986
期刊：
Proceedings of the Royal Society B: Biological Sciences
影响因子：
--
作者：
C. Wysocki;N. Jay Bean;Gary K. Beauchamp
通讯作者：
C. Wysocki;N. Jay Bean;Gary K. Beauchamp
影响因子：
64.8
作者：
Haga, Sachiko;Hattori, Tatsuya;Touhara, Kazushige
通讯作者：
Touhara, Kazushige