Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study.
Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study.
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DOI：
10.1002/ijc.33048
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发表时间：
2020-11-15
影响因子：
6.4
通讯作者：
Witte JS
中科院分区：
文献类型：
--
作者：
Meyers TJ;Weiner AB;Graff RE;Desai AS;Cooley LF;Catalona WJ;Hanauer SB;Wu JD;Schaeffer EM;Abdulkadir SA;Kundu SD;Witte JS
炎症性肠病（IBD）是结直肠癌的既定危险因素。最近的报告表明IBD也是前列腺癌（PC）的危险因素，需要进一步研究。我们研究了2006年至2010年期间进入研究的基于人群的英国生物库队列中的218084名男性，年龄在40至69岁之间，随访至2015年中期。我们使用多变量考克斯回归分析评估IBD和随后的PC之间的关联，调整评估时的年龄、种族、英国地区、吸烟状况、饮酒频率、体重指数、汤森痴呆指数、PC家族史和既往前列腺特异性抗原检测。入组研究时的平均年龄为56岁，94%的男性为白色，1.1%（n = 2311）诊断为IBD。在中位随访78个月后，IBD男性患者PC风险增加（调整后风险比[aHR] = 1.31，95%置信区间[CI] = 1.03-1.67，P = 0.029）。仅在溃疡性结肠炎（UC; aHR = 1.47，95% CI = 1.11-1.95，P = 0.0070）男性中与PC相关，而在克罗恩病（aHR 1.06，95% CI = 0.63-1.80，P = 0.82）男性中与PC无关。由于缺乏关于医疗保健互动频率的数据，结果有限。在一项大规模的前瞻性队列研究中，我们检测到IBD和UC之间的相关性，特别是与PC诊断的相关性。
Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD is also a risk factor for prostate cancer (PC) require further investigation. We studied 218 084 men in the population-based UK Biobank cohort, aged 40 to 69 at study entry between 2006 and 2010, with follow-up through mid-2015. We assessed the association between IBD and subsequent PC using multivariable Cox regression analyses, adjusting for age at assessment, ethnic group, UK region, smoking status, alcohol drinking frequency, body mass index, Townsend Deprivation Index, family history of PC and previous prostate-specific antigen testing. Mean age at study entry was 56 years, 94% of the men were white, and 1.1% (n = 2311) had a diagnosis of IBD. After a median follow-up of 78 months, men with IBD had an increased risk of PC (adjusted hazard ratio [aHR] = 1.31, 95% confidence interval [CI] = 1.03–1.67, P = .029). The association with PC was only among men with the ulcerative colitis (UC; aHR = 1.47, 95% CI = 1.11–1.95, P = .0070), and not Crohn’s disease (aHR 1.06, 95% CI = 0.63–1.80, P = .82). Results are limited by lack of data on frequency of health care interactions. In a large-scale, prospective cohort study, we detected an association between IBD, and UC specifically, with incident PC diagnosis.
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