Electronics with shape actuation for minimally invasive spinal cord stimulation.
Electronics with shape actuation for minimally invasive spinal cord stimulation.
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用于微创脊髓刺激的形状驱动电子设备。
DOI：
10.1126/sciadv.abg7833
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发表时间：
2021-06
期刊：
影响因子：
13.6
通讯作者：
Barone DG
中科院分区：
文献类型：
--
作者：
Woodington BJ;Curto VF;Yu YL;Martínez-Domínguez H;Coles L;Malliaras GG;Proctor CM;Barone DG
在体内改变形状的电子设备使脊柱植入物的锁孔手术能够治疗严重的疼痛。脊髓刺激是最古老和最成熟的神经调节疗法之一。然而，今天，临床医生需要在需要在全身麻醉下进行侵入性手术的笨重桨式器械和可在局部麻醉下通过简单的针穿刺植入但与桨式器械相比具有临床缺点的经皮导线式器械之间进行选择。通过应用光刻和软光刻制造，我们已经开发出一种具有薄，柔性电子器件和集成流体通道的设备。该装置可以卷起成标准经皮穿刺针的形状，然后植入感兴趣的部位，然后在原位扩张，展开成其桨式构造。该器械和植入程序已在体外和人体尸体模型上得到确认。该设备为形状变化的生物电子设备铺平了道路，这些设备提供了用于感测或刺激的大足迹，但以微创方式植入患者体内。
Electronics that change shape inside the body enable keyhole surgery of spinal implants that can treat severe pain. Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead–type devices, which can be implanted via simple needle puncture under local anesthetic but offer clinical drawbacks when compared with paddle devices. By applying photo- and soft lithography fabrication, we have developed a device that features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle-type conformation. The device and implantation procedure have been validated in vitro and on human cadaver models. This device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are implanted in patients percutaneously in a minimally invasive fashion.
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影响因子：
19
作者：
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DOI：
10.1088/0960-1317/18/6/067001
发表时间：
2008-06-01
影响因子：
2.3
作者：
Eddings, Mark A.;Johnson, Michael A.;Gale, Bruce K.
通讯作者：
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