Biological contribution to social influences on alcohol drinking: evidence from animal models.
Biological contribution to social influences on alcohol drinking: evidence from animal models.
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DOI：
10.3390/ijerph7020473
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发表时间：
2010-02
影响因子：
--
通讯作者：
Ryabinin AE
中科院分区：
文献类型：
--
作者：
Anacker AM;Ryabinin AE
社会因素对酗酒事件有很大影响，进而影响公众健康。然而，很难评估这种影响是仅仅是一种文化现象，还是有生物学基础。对非人类灵长类动物的研究表明，个体在早期发育过程中受到的教育方式会影响他们未来酗酒的倾向，而对老鼠的研究表明，社交孤立、拥挤或社会地位低会导致酒精摄入量增加，而社交失败会减少饮酒。参与这些作用的神经递质机制(即5-羟色胺、GABA、多巴胺)已经开始被阐明。然而，这些研究并不排除饮酒的社会影响是通过对负面社会环境的普遍压力反应而发生的可能性。在积极的社交环境中，酒精摄入量也会增加，例如，在与醉酒的同伴互动后，大鼠的酒精摄入量也会增加。最近的研究也开始适应一种新的啮齿动物物种--草原田鼠，以研究社会环境在饮酒中的作用。草原田鼠在个体之间表现出高度的社会联系，许多参与调节这些社会行为的神经化学机制(例如，多巴胺、中枢加压素和促肾上腺皮质激素释放因子系统)也被认为参与了酒精摄入量的调节。纳曲酮是一种阿片受体拮抗剂，被批准用于酒精中毒患者的药物治疗，最近被证明可以降低田鼠的伴侣偏好和酒精偏好。这些发现有力地表明，社会因素影响饮酒的机制有生物学根源，可以使用迅速发展的新动物模型进行研究。
Social factors have a tremendous influence on instances of heavy drinking and in turn impact public health. However, it is extremely difficult to assess whether this influence is only a cultural phenomenon or has biological underpinnings. Research in non-human primates demonstrates that the way individuals are brought up during early development affects their future predisposition for heavy drinking, and research in rats demonstrates that social isolation, crowding or low social ranking can lead to increased alcohol intake, while social defeat can decrease drinking. Neurotransmitter mechanisms contributing to these effects (i.e., serotonin, GABA, dopamine) have begun to be elucidated. However, these studies do not exclude the possibility that social effects on drinking occur through generalized stress responses to negative social environments. Alcohol intake can also be elevated in positive social situations, for example, in rats following an interaction with an intoxicated peer. Recent studies have also begun to adapt a new rodent species, the prairie vole, to study the role of social environment in alcohol drinking. Prairie voles demonstrate a high degree of social affiliation between individuals, and many of the neurochemical mechanisms involved in regulation of these social behaviors (for example, dopamine, central vasopressin and the corticotropin releasing factor system) are also known to be involved in regulation of alcohol intake. Naltrexone, an opioid receptor antagonist approved as a pharmacotherapy for alcoholic patients, has recently been shown to decrease both partner preference and alcohol preference in voles. These findings strongly suggest that mechanisms by which social factors influence drinking have biological roots, and can be studied using rapidly developing new animal models.
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影响因子：
3
作者：
CARTER, CS;GETZ, LL
通讯作者：
GETZ, LL
DOI：
10.1097/01.alc.0000067976.62827.ed
发表时间：
2003-05-01
影响因子：
3.2
作者：
Barr, CS;Newman, TK;Higley, JD
通讯作者：
Higley, JD
影响因子：
5.3
作者：
Aragona, BJ;Liu, Y;Wang, ZX
通讯作者：
Wang, ZX
影响因子：
2.2
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
通讯作者：
Spear, LP
影响因子：
3.3
作者：
Curtis, J. T.;Wang, Z.
通讯作者：
Wang, Z.