Increased basal and alum-induced interleukin-6 levels in geriatric patients are associated with cardiovascular morbidity.
Increased basal and alum-induced interleukin-6 levels in geriatric patients are associated with cardiovascular morbidity.
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DOI：
10.1371/journal.pone.0081911
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Goriely S
中科院分区：
文献类型：
--
作者：
Compté N;Boudjeltia KZ;Vanhaeverbeek M;De Breucker S;Pepersack T;Tassignon J;Trelcat A;Goriely S
低度全身性炎症被认为参与了老年患者生理功能的下降和脆弱性的增加。老年综合征包括各种特征，如功能依赖、多发病、抑郁和营养不良。在老年人群中，心血管疾病和相关风险因素以及慢性巨细胞病毒感染的患病率很高。由于这些基础疾病被认为会影响炎症状态，因此本研究的目的是评估它们对老年综合征与炎症参数相关性的潜在贡献。我们招募了100名普通人群或因慢性疾病住院的受试者（年龄，23-96岁）。我们收集了有关临床状态（病史、正在进行的合并症、治疗和老年量表）、生物学参数（血液学检查、巨细胞病毒血清学）和细胞因子产生（基础和明矾诱导的白细胞介素（IL）-1β和IL-6水平）的信息。使用逐步向后多变量分析，我们确定了哪些临床和生物学变量可以预测炎症标志物的增加。我们证实了年龄相关的循环IL-6水平的增加。与老年量表相反，我们发现心血管疾病史与该参数密切相关，因为在用明矾离体刺激后产生高IL-6。低度炎症和老年疾病之间的关联可能与潜在的心血管疾病有关。
Low-grade systemic inflammation was suggested to participate to the decline of physiological functions and increased vulnerability encountered in older patients. Geriatric syndromes encompass various features such as functional dependence, polymorbidity, depression and malnutrition. There is a strong prevalence of cardiovascular diseases and related risk factors and chronic cytomegalovirus infections in the geriatric population. As these underlying conditions were proposed to influence the inflammatory state, the aim of this study was to assess their potential contribution to the association of geriatric syndromes with inflammatory parameters. We recruited 100 subjects in the general population or hospitalized for chronic medical conditions (age, 23-96 years). We collected information on clinical status (medical history, ongoing comorbidities, treatments and geriatric scales), biological parameters (hematological tests, cytomegalovirus serology) and cytokines production (basal and alum-induced interleukin (IL)-1β and IL-6 levels). Using stepwise backward multivariate analyses, we defined which set of clinical and biological variables could be predictive for increased inflammatory markers. We confirmed the age-associated increase of circulating IL-6 levels. In contrast to geriatric scales, we found history of cardiovascular diseases to be strongly associated for this parameter as for high IL-6 production upon ex vivo stimulation with alum. Association between low-grade inflammation and geriatric conditions could be linked to underlying cardiovascular diseases.
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DOI：
10.1111/j.1532-5415.1994.tb01746.x
发表时间：
1994-03-01
影响因子：
6.3
作者：
GRAVENSTEIN, S;DRINKA, P;ERSHLER, WB
通讯作者：
ERSHLER, WB
影响因子：
4
作者：
Chang, Sandy S.;Weiss, Carlos O.;Fried, Linda P.
通讯作者：
Fried, Linda P.
影响因子：
20.3
作者：
Ferrucci, L;Corsi, A;Longo, DL
通讯作者：
Longo, DL
影响因子：
5.3
作者：
Forsey, RJ;Thompson, JM;Wikby, A
通讯作者：
Wikby, A
DOI：
10.1046/j.1532-5415.2002.50605.x
发表时间：
2002-12-01
影响因子：
6.3
作者：
Ferrucci, L;Penninx, BWJH;Guralnik, JM
通讯作者：
Guralnik, JM