Microbial modulation of behavior and stress responses in zebrafish larvae.
Microbial modulation of behavior and stress responses in zebrafish larvae.
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DOI：
10.1016/j.bbr.2016.05.040
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发表时间：
2016-09-15
影响因子：
2.7
通讯作者：
Ericsson AC
中科院分区：
文献类型：
--
作者：
Davis DJ;Bryda EC;Gillespie CH;Ericsson AC
微生物群对行为和压力反应的影响知之甚少。斑马鱼幼虫具有有利于神经免疫研究的独特特征，然而，它们目前未被充分利用于此类研究。在这里，我们使用无菌斑马鱼来确定微生物群对行为和压力测试的影响。微生物群的缺失极大地改变了运动和焦虑相关的行为。此外，在缺乏微生物暴露的幼虫中，对急性应激源的特征反应也被消除。最后，用益生菌植物乳杆菌治疗足以减弱常规饲养的斑马鱼幼虫的焦虑相关行为。这些结果强调了微生物群在通过微生物群-肠-脑轴与中枢神经系统通信中的重要性，并为使用斑马鱼幼虫进行神经免疫研究奠定了基础。
The influence of the microbiota on behavior and stress responses is poorly understood. Zebrafish larvae have unique characteristics that are advantageous for neuroimmune research, however, they are currently underutilized for such studies. Here, we used germ-free zebrafish to determine the effects of the microbiota on behavior and stress testing. The absence of a microbiota dramatically altered locomotor and anxiety-related behavior. Additionally, characteristic responses to an acute stressor were also obliterated in larvae lacking exposure to microbes. Lastly, treatment with the probiotic Lactobacillus plantarum was sufficient to attenuate anxiety-related behavior in conventionally-raised zebrafish larvae. These results underscore the importance of the microbiota in communicating to the CNS via the microbiome-gut-brain axis and set a foundation for using zebrafish larvae for neuroimmune research.
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影响因子：
3.7
作者：
Hart ML;Meyer A;Johnson PJ;Ericsson AC
通讯作者：
Ericsson AC
影响因子：
1.3
作者：
Colwill, Ruth M.;Creton, Robbert
通讯作者：
Creton, Robbert
影响因子：
2.9
作者：
Giacomini, NJ;Rose, B;Guo, S
通讯作者：
Guo, S
影响因子：
3
作者：
De Marco, Rodrigo J.;Groneberg, Antonia H.;Ryu, Soojin
通讯作者：
Ryu, Soojin
影响因子：
2
作者：
Gioacchini, Giorgia;Giorgini, Elisabetta;Carnevali, Oliana
通讯作者：
Carnevali, Oliana