Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner.
Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner.
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DOI：
10.1016/j.neuroimage.2011.03.070
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发表时间：
2011-07-01
期刊：
影响因子：
5.7
通讯作者：
McNab, Jennifer A.
中科院分区：
文献类型：
--
作者：
Miller, Karla L.;Stagg, Charlotte J.;Douaud, Gwenaelle;Jbabdi, Saad;Smith, Stephen M.;Behrens, Timothy E. J.;Jenkinson, Mark;Chance, Steven A.;Esiri, Margaret M.;Voets, Natalie L.;Jenkinson, Ned;Aziz, Tipu Z.;Turner, Martin R.;Johansen-Berg, Heidi;McNab, Jennifer A.
死后大脑的扩散成像具有很大的潜力，既可以作为脑标本进行切片的参考，也可以作为体内扩散研究和“金标准”组织学/解剖之间的联系。虽然有一个相对成熟的文献对动物死后扩散成像，人类大脑已被证明更具挑战性，由于其与高性能扫描仪的不兼容性。本研究提出了一种方法，死后扩散成像的整个，人脑使用临床3特斯拉扫描仪与3D分割EPI自旋回波序列。给出了11个脑在0.94 × 0.94 × 0.94 mm分辨率下的结果，以及单个脑在0.73 × 0.73 × 0.73 mm分辨率下的结果。扩散张量参数的感兴趣区域分析表明，这些特性与体内相比发生了改变（扩散率和各向异性降低），并显著依赖于死后间隔（从死亡到固定的时间）。尽管有这些改变，弥散纤维束成像的几个主要的管道是成功地证明了这两个决议。我们还报告了皮质各向异性和部分体积效应的新发现。尸检人脑扩散MRI的采集和处理协议。尸检和扫描间隔对扩散指数的影响。死后人类大脑中的纤维束成像。皮质灰质的径向扩散各向异性。
Diffusion imaging of post mortem brains has great potential both as a reference for brain specimens that undergo sectioning, and as a link between in vivo diffusion studies and “gold standard” histology/dissection. While there is a relatively mature literature on post mortem diffusion imaging of animals, human brains have proven more challenging due to their incompatibility with high-performance scanners. This study presents a method for post mortem diffusion imaging of whole, human brains using a clinical 3-Tesla scanner with a 3D segmented EPI spin-echo sequence. Results in eleven brains at 0.94 × 0.94 × 0.94 mm resolution are presented, and in a single brain at 0.73 × 0.73 × 0.73 mm resolution. Region-of-interest analysis of diffusion tensor parameters indicate that these properties are altered compared to in vivo (reduced diffusivity and anisotropy), with significant dependence on post mortem interval (time from death to fixation). Despite these alterations, diffusion tractography of several major tracts is successfully demonstrated at both resolutions. We also report novel findings of cortical anisotropy and partial volume effects. ► Acquisition and processing protocols for diffusion MRI of post-mortem human brains. ► Effect of post-mortem and scan intervals on diffusion indices. ► Tractography in post-mortem human brains. ► Radial diffusion anisotropy in cortical gray matter.
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