Cross-subtype immunity against avian influenza in persons recently vaccinated for influenza.
Cross-subtype immunity against avian influenza in persons recently vaccinated for influenza.
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DOI：
10.3201/eid1401.061283
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发表时间：
2008-01
影响因子：
11.8
通讯作者：
Poccia, Fabrizio
中科院分区：
文献类型：
--
作者：
Gioia, Cristiana;Castilletti, Concetta;Tempestilli, Massimo;Piacentini, Paola;Bordi, Licia;Chiappini, Roberta;Agrati, Chiara;Squarcione, Salvatore;Lppolito, Giuseppe;Puro, Vincenzo;Capobianchi, Maria R.;Poccia, Fabrizio
季节性流感疫苗接种可诱导针对禽流感病毒（H5 N1）的异亚型免疫。禽流感病毒（H5 N1）可传染给人类，导致严重或致命的疾病。本研究的目的是评估接种季节性甲型流感（H1N1）/（H3 N2）疫苗的健康献血者中人和禽流感（H5 N1）毒株之间的免疫交叉反应性。在基线时，在几个人中检测到H5 N1亚型特异性CD 4 T细胞的频率很低，季节性疫苗接种增强了这种反应性CD 4 T细胞的频率。我们还观察到，季节性疫苗接种能够提高大量献血者对流感（H5 N1）的中和免疫力。未观察到流感特异性CD 4 T细胞与体液应答之间的相关性。N1可能是细胞和体液交叉免疫的靶点，但需要更多的实验来阐明这一点。这些发现强调了通过季节性流感疫苗接种增强针对高致病性禽流感A病毒亚型H5 N1的交叉型细胞和体液免疫的可能性。
Seasonal influenza vaccination may induce heterosubtypic immunity against avian influenza virus (H5N1). Avian influenza virus (H5N1) can be transmitted to humans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian influenza (H5N1) strains in healthy donors vaccinated for seasonal influenza A (H1N1)/(H3N2). A small frequency of CD4 T cells specific for subtype H5N1 was detected in several persons at baseline, and seasonal vaccine administration enhanced the frequency of such reactive CD4 T cells. We also observed that seasonal vaccination is able to raise neutralizing immunity against influenza (H5N1) in a large number of donors. No correlation between influenza-specific CD4 T cells and humoral responses was observed. N1 may possibly be a target for both cellular and humoral cross-type immunity, but additional experiments are needed to clarify this point. These findings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian influenza A virus subtype H5N1 by seasonal influenza vaccination.
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DOI：
10.1177/039463200501800312
发表时间：
2005-07-01
影响因子：
3.5
作者：
Gioia, C;Horejsh, D;Poccia, F
通讯作者：
Poccia, F
影响因子：
11.8
作者：
Chan, PKS
通讯作者：
Chan, PKS
影响因子：
5.4
作者：
Seo, SH;Webster, RG
通讯作者：
Webster, RG
影响因子：
11.8
作者：
Kilbourne ED
通讯作者：
Kilbourne ED
影响因子：
3.3
作者：
COLLINS, SD;LEHMANN, J
通讯作者：
LEHMANN, J