Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle.
Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle.
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在毛囊形态发生和诱发毛发周期期间，Sox10的表达和定位。
DOI：
10.7150/ijms.60728
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发表时间：
2021
影响因子：
3.6
通讯作者：
Lu ZF
中科院分区：
文献类型：
--
作者：
Jing J;Xu P;Xu JL;Ding YX;Yang XS;Jin XQ;Zhou LJ;Chen YH;Wu XJ;Lu ZF
Sox转录因子在发育过程中发挥着多种作用，包括调节干细胞状态、指导分化和影响局部染色质景观。Sox10参与了干细胞/祖细胞活性和上皮-间质转化的控制，但尚未研究其与毛囊周期或毛囊干细胞（HFSC）控制的关系。为了阐明Sox10在毛囊周期控制中的作用，我们对其在毛发形态发生、出生后毛发周期和脱毛诱导的小鼠毛囊周期中的表达进行了免疫组织化学和免疫荧光分析。在毛囊形态发生过程中，Sox10在毛芽和peg中表达。在休止期，我们在HFSCs所在的毛囊和生殖细胞帽中检测到Sox10核，而在生长期和退化期，在上皮部分，如角质形成细胞链、生长期的外根鞘（ORS）和退化期的毛囊上皮链中检测到Sox10核。这些结果提示Sox10可能参与了早期毛囊形态发生和出生后毛囊循环。
Sox transcription factors play many diverse roles during development, including regulating stem cell states, directing differentiation, and influencing the local chromatin landscape. Sox10 has been implicated in the control of stem/progenitor activity and epithelial-mesenchymal transition, yet it has not been studied in relation to the hair follicle cycle or hair follicle stem cell (HFSC) control. To elucidate the role of Sox10 in hair follicle cycle control, we performed immunohistochemical and immunofluorescence analysis of its expression during hair morphogenesis, the postnatal hair cycle, and the depilation-induced murine hair follicle cycle. During hair follicle morphogenesis, Sox10 was expressed in the hair germ and peg. In telogen, we detected nuclear Sox10 in the hair bulge and germ cell cap, where HFSCs reside, while in anagen and catagen, Sox10 was detected in the epithelial portion, such as the strands of keratinocytes, the outer root sheath (ORS) in anagen, and the regressed epithelial strand of hair follicle in catagen. These results suggest that Sox10 may be involved in early hair follicle morphogenesis and postnatal follicular cycling.
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影响因子：
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作者：
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DOI：
10.1097/pas.0000000000000398
发表时间：
2015-06
期刊：
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影响因子：
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