Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment.
Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment.
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DOI：
10.1016/j.actbio.2013.03.005
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发表时间：
2013-07
影响因子：
9.7
通讯作者：
Berkland, C.
中科院分区：
文献类型：
--
作者：
Fakhari, A.;Berkland, C.
透明质酸（HA）是一种天然存在的可生物降解的聚合物，在医学中具有多种应用，包括用于组织工程的支架、皮肤病学填充剂和用于骨关节炎治疗的粘弹性补充剂。HA存在于体液中的大多数结缔组织中，例如滑液和眼睛的玻璃体液。HA作为细胞外基质（ECM）的组分负责组织的几种结构特性，并且参与细胞信号传导。HA的降解是一个逐步过程，可通过酶促或非酶促反应发生。HA质量或分子量通过降解或合成减慢而降低会影响物理和化学性质，如组织体积、粘度和弹性。本文综述了HA的分布、周转和组织特异性。该信息被用作考虑最近的产品和策略的背景下修改HA的粘弹性在组织工程中，作为一种真皮填料，并在骨关节炎治疗。
Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of applications in medicine including scaffolding for tissue engineering, dermatological fillers, and viscosupplementation for osteoarthritis treatment. HA is available in most connective tissues in body fluids such as synovial fluid and the vitreous humor of the eye. HA is responsible for several structural properties of tissues as a component of extracellular matrix (ECM) and is involved in cellular signaling. Degradation of HA is a step-wise process that can occur via enzymatic or non-enzymatic reactions. A reduction in HA mass or molecular weight via degradation or slowing of synthesis affects physical and chemical properties such as tissue volume, viscosity, and elasticity. This review addresses the distribution, turnover, and tissue-specific properties of HA. This information is used as context for considering recent products and strategies for modifying the viscoelastic properties of HA in tissue engineering, as a dermal filler, and in osteoarthritis treatment.
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