The Cooking and Pneumonia Study (CAPS) in Malawi: A Cross-Sectional Assessment of Carbon Monoxide Exposure and Carboxyhemoglobin Levels in Children under 5 Years Old.
The Cooking and Pneumonia Study (CAPS) in Malawi: A Cross-Sectional Assessment of Carbon Monoxide Exposure and Carboxyhemoglobin Levels in Children under 5 Years Old.
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DOI：
10.3390/ijerph15091936
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发表时间：
2018-09-05
影响因子：
--
通讯作者：
Mortimer K
中科院分区：
文献类型：
--
作者：
Havens D;Wang D;Grigg J;Gordon SB;Balmes J;Mortimer K
据估计，家庭空气污染导致全球50万儿童死于肺炎。烹饪和肺炎研究(CAPS)是为了确定使用更清洁的燃烧生物质的炉灶是否会减少家庭空气污染，从而减少马拉维农村地区幼儿肺炎的发病率。在这里，我们报告了一项关于一氧化碳(CO)暴露和碳氧血红蛋白(COHgB)水平的横断面评估。1928名参与调查的儿童48小时平均一氧化碳暴露水平为0.90(2.3；0-49)ppm，平均(SD；范围)COHgB水平为5.8%(3.3；0-20.3)。CO和COHgB的平均水平与地点有关(奇瓦瓦和奇伦巴)(OR 3.55(1.73-7.26))；(OR 2.77(1.08-7.08))。平均CO与COHgB相关性较差(Spearman‘sρ=0.09，p<；0.001)。令人关切的是，马拉维农村地区幼儿的COHgB水平很高，达到了对神经发育和认知产生不利影响的水平。迫切需要在撒哈拉以南非洲农村地区减少接触一氧化碳和其他空气污染成分的有效方法。
Household air pollution is estimated to cause half a million deaths from pneumonia in children worldwide. The Cooking and Pneumonia Study (CAPS) was conducted to determine whether the use of cleaner-burning biomass-fueled cookstoves would reduce household air pollution and thereby the incidence of pneumonia in young children in rural Malawi. Here we report a cross-sectional assessment of carbon monoxide (CO) exposure and carboxyhemoglobin (COHgB) levels at recruitment to CAPS. Mean (SD; range) 48-h CO exposure of 1928 participating children was 0.90 (2.3; 0–49) ppm and mean (SD; range) COHgB level was 5.8% (3.3; 0–20.3). Higher mean CO and COHgB levels were associated with location (Chikhwawa versus Chilumba) (OR 3.55 (1.73–7.26)); (OR 2.77 (1.08–7.08)). Correlation between mean CO and COHgB was poor (Spearman’s ρ = 0.09, p < 0.001). The finding of high COHgB levels in young children in rural Malawi that are at levels at which adverse neurodevelopmental and cognitive effects occur is of concern. Effective approaches for reducing exposure to CO and other constituents of air pollution in rural sub-Saharan African settings are urgently needed.
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